Second Generation of Liquid-Based Cytology

Second Generation of Liquid-Based Cytology PowerPoint PPT Presentation


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2. Testing for Cervical Cancer Screening was introduced in 1947 by Dr. George Papanicolaou called the

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Second Generation of Liquid-Based Cytology

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7. Comparison of Gyn Data

11. Cytology Technology Evolution

14. 1st Generation LBC Fundamental Design Flaws Reagent design was to accommodate limitation of 1980 readers: i.e. ?ThinPrep monolayer ?SurePath StainMate (standardized stains required for readers) • No cost considerations i.e. ?hazmat reagents cost more to ship & to dispose ?chemically charged slides /pre-treated slides (poly-L-lysine) ?expensive plastic disposables • Specimen Variation (gyn vs non-gyn) i.e. ?bloody/mucoid specimens (clogged filters), acid pre-treatments ?50ul (FNA) to 1500 ml (plural fluid) • Instrumentation or mechanization ?? i.e. ?one specimen at a time (TP2000) ?already own a slide stainer (StainMate is a microplate pipettor)

18. It’s in the chemistry! Preservative Solution- - alcohol based, non-hazmat - no morphologic changes, no special teaching to read - patent pending Cleaning Solution- - optional usage - separation gradient removes blood and mucus Lytic Reagent- - to clean mucoid specimens - 3+/4+ bloody specimens - supplement to Cleaning Solution Cell Base - - adhesive with porous properties - uses standard slides - protects nucleic acids and proteins

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