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Multimodal Imaging in Clinical Neuroscience: Simultaneous MR – PET – EEG

Multimodal Imaging in Clinical Neuroscience: Simultaneous MR – PET – EEG. Irene Neuner , Tracy Warbrick, Jörg Mauler, Joachim B. Kaffanke, Elena Rota Kops, Christoph Weirich, Frank Boers, Jürgen Scheins, Karl-Josef Langen, Hans Herzog and N. Jon Shah. Social Dimension. Lesch 2005, Kawohl 2012.

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Multimodal Imaging in Clinical Neuroscience: Simultaneous MR – PET – EEG

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  1. Multimodal Imaging in Clinical Neuroscience:Simultaneous MR – PET – EEG Irene Neuner, Tracy Warbrick, Jörg Mauler, Joachim B. Kaffanke, Elena Rota Kops, Christoph Weirich, Frank Boers, Jürgen Scheins, Karl-Josef Langen, Hans Herzog and N. Jon Shah

  2. Social Dimension Lesch 2005, Kawohl 2012

  3. High Very Good Good Low Very Low Current MRI Anatomy Molecular Imaging Function Sensitivity/Specificity Temporal Clinical Utility Spatial Clinical Availability Development Prospects Technological Maturity

  4. High Very Good Good Low Very Low Current PET Anatomy Molecular Imaging Function Sensitivity/Specificity Temporal Clinical Utility Spatial Clinical Availability Development Prospects Technological Maturity

  5. High Very Good Good Low Very Low Hybrid MR-PET Anatomy Molecular Imaging Function Sensitivity/Specificity Temporal Clinical Utility Spatial Clinical Availability Development Prospects Technological Maturity

  6. Head coil 3T Hybrid MR-PET

  7. Protocol example • LOCALIZER localizer 00:27 • ATTENUATION / CSI planning mprage_1x1x1sag_pat2_bw610 04:40 • ATTENUATION UTE_417_32K_192_15 06:40 • ANATOM. DIAGNOSTIC t2_tirm_tra_dark-fluid 04:27 • fMRI ep2d_bold_restingstate 06:06 • DTI ep2d_diff_std 09:55 • SPECTROSCOPY csi_se_30 08:10 • PERFUSION ep2d_fid_perfusion 02:04 • ANATOM. DIAGNOSTIC mprage_1x1x1_sag_pat2_KM 05:14 • 47:43 PET listmode acquisition . MRI acquisition t t + 50 t t + 50 PERF CA CSI MPRAGE DTI FLAIR fMRI UTE localizer 5 8 10 2 5 6 6 4 2

  8. 3T Hybrid MR-PET: fMRI & DTI & PET Neuner et al. In press

  9. Combination electrophysiology and fMRI 1 sec

  10. Startle Reflex and fMRI T-values,FWE corrected, p<0,05, n=15 Neuner et al. 2010 1 sec

  11. EEG at static field 9.4T

  12. EEG at static 9.4T field Same subject, same stimuli, recorded under 9.4T Picked using Independent Component Analysis Auditory stimuli, recorded @ magnetic earth field in a mock scanner

  13. EEG data acquired in the 3T MR and 3T Hybrid MR-PET system • Visual ERPS measured in response to a black and white checkerboard stimulus (200 trials). • Sensory and attention related ERP components identified. • All ERPs shown at occipital electrodes (O1 and O2). • Plots are shown with negative polarity up. • 32 Channel MR-compatible EEG system (Brainproducts, Germany) with MR-compatible cap. • Correction of the gradient artifacts (Allen et al. 2003) and cardiballistic artifact (Brainvision Analyzer 2.0., EEGlab).

  14. 0T (console room of 9.4T scanner) P1 P2

  15. 3T MR P1 P2

  16. 3T Hybrid MR-PET P1 P2

  17. 3T MR and 3T Hybrid MR-PET Black – Trio Red – MR-PET

  18. EEG Summary • Factors remaining the same across recordings: • Amplifier • Cap • Subject • Paradigms • Factors differing across recordings: • Screen • Distance from screen • Coil • Amplifier position • Subject position • Possible things to test to improve data quality: • ICA for correction • Amplifier position in MR-PET • Cable position and securing • Electronics of MR-PET

  19. Thank you very much for your attention! • Jorge Arrubla • Frank Boers • Avdo Celik • Jörg Felder • Christian Filss • Hans Herzog • Karl-Josef Langen • Jörg Mauler • Jürgen Scheins • N.J. Shah • Gabriele Stoffels • Lutz Tellmann • Markus Ullisch • Tracy Warbrick • Christoph Weirich Black – Trio Red – MR-PET

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