Foundation for the National Institutes of Health

1. Foundation for the National Institutes of Health Presentation to the Council of Public Representatives Amy McGuire, Executive Director November 3, 2006

2. The FNIH’s mission is to support the mission and priorities of the NIH.

3. The NIH Roadmap • Through the NIH Roadmap, NIH aims to: • Accelerate the pace of discovery • Speed the application of new knowledge to the development of new prevention strategies, new diagnostics and new treatments, • Transfer these innovations to health care providers, and the public • Priorities include: • New Pathways to Discovery: investing in new areas of research • Re-Engineering the Clinical Research Enterprise: harmonizing policies, developing new training and tools, and fostering translational research • Research Teams of the Future: supporting interdisciplinary research, high-risk research, and public-private partnerships

4. Foundation for NIH Overview • Independent nonprofit organization created by U.S. Congress in 1990, incorporated in 1996 • Sole entity authorized by Congress to raise private funds to support all aspects of NIH’s mission: improving health through scientific discovery • Creates innovative public-private partnerships involving industry, academia, the philanthropic community that complement and enhance NIH priorities and activities • Governed by independent Board of Directors, including NIH Director and FDA Commissioner as ex-officio, non-voting members

5. What does FNIH bring to public-private partnerships to support research? • Creates a unique platform for industry and non-profits to work together during the pre-competitive stage. • Is authorized to include NIH and other government agencies at the table - FDA and CMS. • Access to increased revenues. • Use of broad, cross-sector expertise. • Provides flexibility and quick turnaround time for decision-making, financial and communications services. FNIH is recognized as successful in facilitating public-private partnerships to support biomedical research. McKinsey & Company and the Institute of Medicine have pointed to FNIH as an example to be followed.

6. In addition, FNIH… • Works closely with all partners • Ensures correct players are involved for successful program design and implementation • Allows industry and donors to participate in concept development and other activities • Ensures private funds received for partnership are spent appropriately; align to donors’ initial intentions • Accesses expertise and of FNIH’s Board of Directors

7. Foundation partnerships have focused on topics such as: Global Health • Grand Challenges in Global Health (GCGH) • Bill & Melinda Gates Foundation, CIHR, Wellcome Trust • $453 million ($200 million managed by FNIH) Genomics • Genetic Association Information Network (GAIN) • Pfizer, Affymetrix, Broad Institute, Abbott, others • $18.9 million to date • Mouse Sequencing Consortium • Merck, Affymetrix, GlaxoSmithKline • $16 million Biomarker research • Alzheimer’s Disease Neuroimaging Initiative (ADNI) • 10 pharmaceutical and biotech companies, 2 non-profits • $22 million to date • Osteoarthritis Initiative (OAI) • Merck, Novartis, Pfizer, GlaxoSmithKline • $20.8 million to date

8. Program and FNIH Program Revenuewith projected total revenue for 2006

9. Keys to Successful Partnerships • Leadership by decision-makers, both public and private • Appropriate governance structure and partnership policies and practices • Adequate financial resources • Transparent communication between partners and with stakeholders • Clear recognition of goals and the distinct roles and limitations of each partner

10. What Can You Do? • Identify and propose projects and areas of research that would benefit by a public-private partnership • Suggest new models for collaboration • Suggest possible partners to FNIH • Recommend FNIH to others