kate li chemical engineering biochemistry
Download
Skip this Video
Download Presentation
Kate Li Chemical Engineering & Biochemistry

Loading in 2 Seconds...

play fullscreen
1 / 12

Kate Li Chemical Engineering & Biochemistry - PowerPoint PPT Presentation


  • 78 Views
  • Uploaded on

Kate Li Chemical Engineering & Biochemistry. Characterization of Diffusion from Mesoporous Silica Nanoparticles for Potential Drug-Delivery Applications. Mesoporous Silica Nanoparticles.

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about ' Kate Li Chemical Engineering & Biochemistry' - nell


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
kate li chemical engineering biochemistry
Kate Li

Chemical Engineering & Biochemistry

Characterization of Diffusion from Mesoporous Silica Nanoparticles for Potential Drug-Delivery Applications

mesoporous silica nanoparticles
Mesoporous Silica Nanoparticles

Figure 1: Diagram of different ways to functionalize a mesoporous silica nanoparticle – external and pore surface functionalization (Colila et. al 2013).

why msnps
Why MSNPs?
  • Tunable drug delivery
    • Antibodies for site specificity
    • Within threshold size for cellular uptake (D ~100 nm)
    • Controlled and sustained release
  • Applications: chemo toxic drugs, nonpolar with low bioactivity in the body due to poor solubility
  • Silica is bioinert

Glass cardiovascular system sculpture by Gary Farlow

modified st ber process
Modified Stӧber Process

Reagents:

  • Cetyltetra-ammoniumbutylate (CTAB)
  • Tetraethyl orthosilicate (TEOS)
  • NaOH
  • EtOH
  • Water
experimental procedure
Experimental Procedure
  • Procedure:
  • Add .375 g of CTAB, .4375 mL 2.0 M NaOH and 30 mL dI H2O to roundbottom flask with magnetic stir bar and heat to 80⁰C for 30 minutes.
  • To clear solution, add 2.48 mL TEOS via rapid injection.
  • White precipitate will be observed after 1-2 minutes of stirring.
  • Maintain reaction temperature at 80⁰C for 2 hrs.
  • Isolate product via ethanol wash and centrifugation/sonication cycles of 10 minutes each, four times. Dilute and suspend in ethanol.

Materials:

- TEOS (tetra ethyl orthosilicate)

- EtOH (ethanol)

- CTAB (cetyltrimethylammonium bromide)

- NaOH (sodium hydroxide)

- dI H2O(deionized water)

Characterization:

- N2 absorption

- SEM, TEM, SAXRD

further research
Further research
  • Further research on the parameters of the Modified Stӧber Process
  • Attempting functionalization of surface and pores
  • Generate diffusion data
thank you nasa space grant ua honors college alumni travel grants dr anthony muscat
Thank you

NASA Space Grant

UA Honors College – Alumni Travel Grants

Dr. Anthony Muscat

Questions?

NASA Space Grant Consortium

ad