Acquired Hemolytic Anemias. Prof. Dr. S. Sami Kartı. General features (I). Acquired hemolytic anemias are divided into two main types: immune and non-immune
Prof. Dr. S. Sami Kartı
Immune hemolytic anemias
Do not confuse cold agglutinins with cryoglobulins. Cold agglutinins are
antibodies that cause agglutination of erythrocytes at cold temperatures.
Cryoglobulins are antibodies that aggregate at cold temperatures (no erythrocytes involved)
Primary Cold Agglutinin Disease
Secondary Cold Agglutinin Disease
Paroxysmal cold hemoglobinuria is seen in three clinical forms
Paroxysmal cold hemoglobinuria is a relatively common cause of acute hemolytic anemia in children
Clinical Manifestations (I)
Clinical Manifestations (II)
When PNH should be suspected
The median survival in PNH is approximately 10 to 15 years, and some patients live for 25 years or longer. Rare cases of spontaneous recovery have been reported.