Curcumin C 3 Power ™- Natural Bioprotectant

1. Curcumin C3 Power™- Natural Bioprotectant

2. Curcumin C3 Power™- Natural Bioprotectant Did you Know ? Cardiovasuclar diseases Cholestrol, platelet aggregation, inhibition of smooth muscle cell proliferation Multiple sclerosis Alzheimer disease Diabetes Chemotherapeutic Nephrotoxicity Chemopreventive Skin, liver, colon, stomach Antioxidant Curcumin Antiflammatory Gall-stones formation Arthritis Prevalence of Alzheimer’s Disease & Cancer in South Asia is much less compared to the US & Europe Cataract formation Lung fibrosis Cardiotoxicity HIV replication 2 2 Wound healing

3. Curcumin C3 Power™- Natural Bioprotectant Reports Curcumin and Alzheimer's disease: In light of epidemiological studies that suggest a link between long-term use of non steroidal anti-inflammatory drugs and the reduced incidence of Alzheimer's disease (AD), one group of researchers evaluated whether dietary Curcumin (at low dose 160 ppm and high dose 5000 ppm) would have a similar effect in Alzheimer transgenic APPSw mouse model Curcumin and diabetes: The efficacy of turmeric and curcumin on blood sugar and polyol pathway in diabetic albino rats was examined. Administration of turmeric or curcumin to diabetic rats reduced the blood sugar and glycosylated hemoglobin levels significantly. Curcumin and colon cancer:The efficacy of curcumin in inhibiting the development of adenomas of the intestinal tract has been confirmed in earlier studies. A recent study explored the chemopreventive efficacy and pharmacokinetics of curcumin in the Min/+ Mouse, a model of familial adenomatous polyposis. Curcumin and prostate cancer: Curcumin was shown to enhance cytotoxicity of chemotherapeutic agents in prostate cancer cells by inducing p21 (WAF1/C1P1) and C/EPBbeta, in two androgen-independent prostate cancer cell lines Curcumin and skin cancer: The increased incidence of non-melanoma skin cancer, consisting of basal and squamous cell carcinoma, is a major health concern in recent years and is attributed to the action of solar (UV) B radiation as a result of atmospheric ozone layer depletion.

4. Curcumin C3 Power™- Natural Bioprotectant Curcumin C3 Power™ is a proprietary composition of Curcuminoids containing our patented Bioprotectant Complex – Curcumin C3 Complex® and the natural patented bioavailability enhancer, BioPerine®

5. Curcumin C3 Power™- Natural Bioprotectant The first book to comprehensively list the medicinal claims of Curcuminoids was published by SABINSA in 1993

6. Curcumin C3 Power™- Natural Bioprotectant Actions & Benefits Curcumin C3 Power™ plays powerful Antioxidant, Anti-inflammatory, Anti-bacterial, Anti-fungal, Anti-parasitic, Anti-mutagen, Anti-cancer & Detox roles in biological systems

7. Key Benefits • Helps provide optimal protection and integrity to biological systems • Antioxidant, Anti-carcinogenic, Anti-viral, Antibacterial, Antifungal Activity • Supports overall wellness and good health. • Supports pain and inflammation • Helps maintain healthy liver function • Helps stimulate bile production, which prevent gallstone formation • Helps lowering LDL and raising HDL Cholesterol • Helps prevent Auto-immune disorders. • Helps maintain a normal cholesterol level • Helps eliminate toxins from the body • Antioxidant quenching free radicals and also preventing the free radical formation

8. Curcumin C3 Power™- Natural Bioprotectant OVER 1000 STUDIES DONE ON CURCUMIN WORLDWIDE US PATENT 5861415 US PATENT  5891924

9. Curcumin C3 Power™- Natural Bioprotectant Composition Each Tablet contains: Suggested use level: 1 Tablet twice a day * Patented - US & International Patents

10. Curcumin C3 Power™- Natural Bioprotectant Supporting Studies • Antifibrogenic activity: • Curcumin is reported to inhibit collagen synthesis and hepatic stellate cell activation both in vivo and in vitro. • The authors studied the effects of curcumin on the production of collagen and smooth muscle alpha actin proteins and of alpha(1) collagen mRNA in vivo and in vitro. • Collagen synthesis was found to be lowered both in vitro and in vivo and curcumin was found to reduce DNA synthesis in vitro, and down regulated smooth muscle alpha actin and type1 collagen expression, and alpha(1)collagen mRNA expression, at a concentration of 5 microg/mL. • It was concluded that curcumin may therefore prove to be a valuable anti-fibrogenic agent (Kang et al,2002).

11. Curcumin C3 Power™- Natural Bioprotectant Supporting Studies • Antimutagenic potential: • The antimutagenic effects of curcumin were evaluated in vitro using chromosomal aberration assayinWistar rats, induced by cyclophosphamide, a known carcinogen. • When curcumin was given at a dose of 100 and 200 mg/kg body weight through gastric intubation for seven consecutive days before cyclophosphamide treatment, the incidence of aberrant cells was found to be reduced with both doses of curcumin when compared to a control group treated with cyclophosphamide alone (Shukla et al,2002).

12. Curcumin C3 Power™- Natural Bioprotectant Supporting Studies • Anti-inflammatory effects: • The Cyclooxygenase-2 (COX-2) enzyme plays an important role in colon carcinogenesis. One group of researchers investigated the effect of curcumin on COX-2 expression in HT-29 human colon cancer cells. Curcumin inhibited cell growth in HT-29 cells in a concentration and time dependent manner. Curcumin inhibited mRNA and protein expression in COX-2 but not COX-1 and may have value as a specific inhibitor of COX-2 and a safe chemopreventive agent against colon cancer (Goel et al,2001). • Lipid-lowering effects: • Studies have shown that dietary curcuminoids have lipid-lowering potency in vivo, and the mechanism of action is probably through alterations in fatty acid metabolism (Saleheen, et al, 2002).

13. Curcumin C3 Power™- Natural Bioprotectant Supporting Studies • Antioxidant action: • In a study that explored the role of spice principles and their active components as potential antioxidants, the inhibitory effects of curcumin, quercetin and capsaicin on the oxidation of human low density lipoprotein (LDL) were found to be comparable to that of BHA, but relatively more potent than ascorbic acid. The effects of various spice principles on copper ion-induced lipid peroxidation of LDL was determined by measuring the formation of TBARS (thiobarbituric acid reactive substances) and relative electrophoretic mobility of LDL on agarose gel. Quercetin and curcumin showed the highest inhibitory activity (Naidu and Thippeswamy, 2002).

14. Curcumin C3 Power™- Natural Bioprotectant Supporting Studies • Radioprotective effects: • Curcumin is reported to be potentially useful in preventing the development of radioresistance following radiotherapy. Phenolic compounds such as curcumin, ellagic acid and quercetin, were found to be effective in inhibiting radiation-induced protein kinase C (PKC) activity. Activation of PKC is reported to be one of the means of conferring radioresistance on a tumor cell. Therefore suppression of PKC by phenolics may be a meands of preventing the development of radioresistance following radiotherapy. (Varadkar et al, 2001).

15. Curcumin C3 Power™- Natural Bioprotectant Supporting Studies • Curcumin and cardiovascular diseases • Curcumin and related non-toxic antioxidants from Curcuma longa have a favorable effect on experimental mouse tumorigenesis as well as on inflammatory processes such as psoriasis and ethanol-caused hepatic injury. The authors' research has focused on the effects of diet supplementation with an antioxidant-rich hydroalcoholic extract of the curcuma rhizome on key risk factors of atherogenesis and related cardiovascular disease. In human healthy subjects, the daily intake of 200 mg of the above extract results in a decrease in total blood lipid peroxides as well as in HDL and LDL-lipid peroxidation ( Arch GerontolGeriatr. 2002 ).

16. Curcumin C3 Power™- Natural Bioprotectant Supporting Studies • AntiinInflammatory /Anticancer • Inflammatory Bowel Disease • Numerous therapies used for inflammatory bowel disease (IBD) target the transcription factor NF-kappaB, which is involved in the production of cytokines and chemokines integral for inflammation. The authors show that curcumin, is able to attenuate colitis in the dinitrobenzene sulfonic acid (DNB)-induced murine model of colitis. They also show that the immunohistochemical signal is dramatically attenuated at the level of the mucosa by curcumin. They conclude that curcumin is able to attenuate experimental colitis through a mechanism correlated with the inhibition of the activation of NF-kappaB and effects a reduction in the activity of p38 MAPKwith therapeutic implications for human IBD (Salh et al, 2003).

17. Curcumin C3 Power™- Natural Bioprotectant References 1. Asai, A. and Miyasawa, T. (2001) Dietary curcuminoids prevent high fat diet induced lipid accumulation in rat liver and epididymal adipose tissue. J. Nutr. 131(11):2932-2935 2. Goel, A. et al. (2001) Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells. Cancer Lett. 172(2): 111-118. 3. Kang, H.C. et al. (2002) Curcumin inhibits collagen synthesis and hepatic stellate cell activation in-vivo and in-vitro. J. Pharm. Pharmacol. 54(1):119-26. 4. Koide, T. et al. (2002) Leishmanicidal effects of curcumin in vitro. Biol. Pharm. Bull. 25(1):131-133 5. Naidu KA, Thippeswamy NB.(2002) Inhibition of human low density lipoprotein oxidation by active principles from spices. Mol Cell Biochem 229(1-2):19-23 6. Shukla, Y. et al. (2002) antimutagenic potential of curcumin on chromosomal aberrations in Wistar rats. Mutat. Res . 515(1-2) 197-202 . 7. Saleheen, D. et al. (2002) Latent activity of curcumin against leishmaniasis in vitro. Biol. Pharm. Bull. 25(3):386-389. 8. Varadkar, P. et al. (2001) Modulation of radiation-induced protein kinase C activity by phenolics. J. Radio. Prot. 21(4):361-370.