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GO Annotation from different sources

GO Annotation from different sources. Secondary Sources of GO annotation. EXAMPLES: public databases (eg. NCBI, UniProtKB) genome browsers (eg. Ensembl) array vendors (eg. Affymetrix) CONSIDERATIONS: What is the original source? When was it last updated?

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GO Annotation from different sources

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  1. GO Annotation from different sources

  2. Secondary Sources of GO annotation • EXAMPLES: • public databases (eg. NCBI, UniProtKB) • genome browsers (eg. Ensembl) • array vendors (eg. Affymetrix) • CONSIDERATIONS: • What is the original source? • When was it last updated? • Are evidence codes displayed?

  3. C. Obtaining GO annotations from Secondary Sources AIM: Look at how different public resources and tools display GO.

  4. GO annotation obtained for chick GAPDH (P00356) from different sources: • QuickGO (primary source) • UniProtKB database • NCBI Entrez Gene page • Ensembl browser • Affymetrix chick array • g:profiler gene expression analysis tool

  5. QuickGO

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  8. Comparison of Chicken GAPDH GO annotation obtained from different sources. GO evidence codes not reported.

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