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PolExGene meeting November, 19-20 2009 Ghent

PolExGene meeting November, 19-20 2009 Ghent. CNRS Montpellier (France), Partner 10 Max Mousseron Institute of Biomolecules Pr. Jean Martinez Dr. Muriel Amblard Dr. Gilles Subra Aude Kreiter Pascal Verdié (purification) Luc Brunel (RGD derivatives). WP 2 : Synthesis of Selected CPP.

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PolExGene meeting November, 19-20 2009 Ghent

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  1. PolExGene meeting November, 19-20 2009 Ghent CNRS Montpellier (France), Partner 10 Max Mousseron Institute of Biomolecules Pr. Jean Martinez Dr. Muriel Amblard Dr. Gilles Subra Aude Kreiter Pascal Verdié (purification) Luc Brunel (RGD derivatives) WP 2 : Synthesis of Selected CPP WP 3 : Synthesis of Selected CIP

  2. Objectives of our group Synthesis of Cell Penetrating Peptides (CPP) • Peptides deriving from protein transduction domain (Penetratin) • Polyarginine-based peptides CPP-containing polyplexes (covalent anchoring) CPP + polyplexes (mixtures) Selection and synthesis of Cell Interacting Peptides (CIP) • RGD-based peptides Increase membrane-cell interaction

  3. Cell Penetrating Peptide Synthesis Penetratin and Polyarginine-based peptides delivered since May 2009 Partn n° JMV 3781 1 Ac-Cys-(Arg)8-NH2 Ac-CRRRRRRRR-NH2 JMV 3510 1 Ac-CRQIKIWFQNRRMKWKK-OH Ac-Cys-penetratin

  4. Cell Interacting Peptide Synthesis RGD-based peptides (avb3 integrin) delivered since May 2009 Partn n° 1 H-Cys-Gly-Gly-Arg-Gly-Asp-Ser-OH JMV 3622 cyclo[Arg-Gly-Asp-(D)Phe-Lysw](H-Cys-Gly-Gly-) JMV3619 1

  5. - + Cell Interacting Peptide Synthesis Fibril Forming Sequence: non-integrin ’RADA’ sequences 1 Ac-Cys-(Arg-Ala-Asp-Ala)4-NH2 JMV 4336 Ac-(Arg-Ala-Asp-Ala)4-NH2 JMV 4406 2 Hard to synthezise, hard to analyse, hard to purify Solubilizing in neat TFA

  6. - - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + + + + + + + + + Cell Interacting Peptide Synthesis Fibril Forming Sequence: non-integrin ’RADA’ sequences

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