D9 Drug design. Daniel Brown. D9.1 Discuss the use of a compound library in drug design. Traditionally, a large collection of related compounds are synthesized individually and evaluated for biological properties. However t his is time consuming and expensive.
D9 Drug design
a large number of different compounds and
screen them for biological activity, resulting in
a “combinatorial library”. Combinatorial chemistry involves the rapid synthesis or the computer simulation of a large number of different but structurally related molecules or materials.
D9.4 Discuss how the polarity of a molecule can be modified to increase its aqueous solubility and how this facilitates its distribution around the body.