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Polymorphic SARPs

20. 16. Non-polymorphic SARPs. 12. Polymorphic SARPs. Number of SARPs (x100). 8. 4. 0. L. S. E. P. A. G. K. R. Q. D. V. T. H. F. I. N. C. Y. M. W. Supplementary Figure 1. 16. 12. Amino acid usages in total Proteome.

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Polymorphic SARPs

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  1. 20 16 Non-polymorphic SARPs 12 Polymorphic SARPs Number of SARPs (x100) 8 4 0 L S E P A G K R Q D V T H F I N C Y M W Supplementary Figure 1

  2. 16 12 Amino acid usages in total Proteome Amino acid usages in peptides excluding repeat domains Amino acid usages in repeat domains 8 4 0 P E S A L G K Q R T D V H F I C N Y M W Amino acid usages Supplementary Figure 2

  3. 14 10 12 0 6 8 2 4 ARX, SCA1, DRPLA, SCA6, RUNX2, SACA7 telomeric 6 centromeric 3 HD, PHOX2B, COMP centromeric 2 PABP2, AR CBL2, SCA2, SCA3, SCA17, HOXD13 ASPN, SOX3, ZIC2, FOXL2, HOXA13, DM1, FRAXA,FRDA telomeric 13 No. of disease associated SARPs Supplementary Figure 3

  4. ENVQDLLLLDVAPLSL EKVQDLLLLDVAPLSL ENVQDLLLLDVTPLSL ENVQDLLLLDVTPLSL ENVQDLLLLDVTPLSL ENVQDLLLLDVTPLSL ENVQDLLLLDVTPLSL ENVQDLLLLDVTPLSL ENVQDLLLLDVAPLSL ENVQDLLLLDVAPLSL EKVQDLLLLDVAPLSL EKVQDLLLLDVAPLSL QDTGDLVLLDVCPLTL QDTGDLVLLDVCPLTL QDTGDLVLLDVCPLTL Hs|1367685| Mm|Hspa1b| Hs|HSPA1A| Hs|HSPA1B| Hs|HSPA1L| Mm|Hspa1l| Gg|HSC70| Hs|HSPA8| Mm|Hspa8| Gg|HSPA5| Mm|Hspa5| Hs|HSPA5| Hs|HSPA6| Gg|HSPA8| Mm|Hspa2| Supplementary figure 4A Heat shock protein

  5. EDGEKAAREVKLLLLGAGESGK Gg|GNAI1| EDGEKAAREVKLLLLGAGESGK Hs|NAI1| DDGEKAAREVKLLLLGAGESGK Dr|gnai1| EDGEKAAKEVKLLLLGAGESGK Gg|Galphai3| EDGEKAAKEVKLLLLGAGESGK Mm|Gnai3| EDGEKAAKEVKLLLLGAGESGK Hs|GNAI3| EDGEKTAREVKLLLLGAGESGK Tr|Gnai2| --------EVKLLLLGAGESGK Dr|gnai2| EDGEKAAREVKLLLLGAGESGK Xl|Unknown| EDGEKAAREVKLLLLGAGESGK Gg|GNAI2| EDGEKAAREVKLLLLGAGESGK Hs|GNAI2| EDGEKAAREVKLLLLGAGESGK Mm|Gnai2| EDADKDARTVKLLLLGAGESGK XL|gnat| EDAEKDARTVKLLLLGAGESGK Gg|GNAT1| EDAEKDARTVKLLLLGAGESGK Tr|Gnat1| EDAEKDARTVKLLLLGAGESGK Hg|GNAT1| EDAEKDARTVKLLLLGAGESGK Mm|Gnat1| EDADKDARTVKLLLLGAGESGK Dr|gnat1| EDADKDARTVKLLLLGAGESGK Dr|gnat1| EDADKEAKTVKLLLLGAGESGK Dr|gnat2| EDAAIDAKTVKLLLLGAGESGK Xl|MGC84412| EDADKEAKTVKLLLLGAGESGK Gg|LOC395425| EDADKEAKTVKLLLLGAGESGK Hs|GNAT2| EDADKEAKTVKLLLLGAGESGK Mm|Gnat2| EDAEREARTVKLLLLGAGESGK Gg|LOC427851| EDAERDARTVKLLLLGAGESGK Hs|GNAT3| EDAERDARTVKLLLLGAGESGK Mm|LOC242851| EDGISAAKDVKLLLLGAGESGK Hs|GNAO1| EDGISAAKDVKLLLLGAGESGK Mm|Gnao| EDGITAAKDVKLLLLGAGESGK Dr|gnao1| EDGVTAAKDVKLLLLGAGESGK XL|XGalpha01| SESQRQRREIKLLLLGTSNSGK Tr|Gnaz| SESQRQRREIKLLLLGTSNSGK Hs|GNAZ| SESQRQRREIKLLLLGTSNSGK Mm|GnazL| EDGEKAAREVKLLLLGAGESGK Xl|gnai1-prov| Guanine binding proteins Supplementary figure4B

  6. VTERAEDEEEINAELTAKK VTERAEDEEEINAELTAKK VTERAEDEEEINAELTAKK LSRQVEEEEEINSELTARGR LSERVEEEEEINSELTARGR VTERAEDEEEINAELTAKKR VTERAEDEEEINAELTAKKR VTERAEDEEEINAELTAKKR LTERAEDEEEINAELTAKKR VTERAEEEEEINAELTAKKR MTERLEDEEEMNAELTAKKR MNERLEDEEEMNAELTAKKR LTERAEDEEEMNAELTAKK MTERLEDEEEMNAELTAKK LTERLEEEEEMNSELVAKK MTERLEEEEEMNAELAAKK MNERLEDEEEMNAELTAKK Mm|LOC383154| Gg|LOC417306| Hs|MYH13| Hs|MYH15| Hs|MYH1| Mm|MYSc| Hs|MYH6| Mm|Myh1| Gg|MYH7| Mm|Myh6| Mm|Myh7| Hs|MYH7| Gg|MYH2| Hs|MYH3| Mm|Myh4| Hs|MYH8| Hs|MYH4| Supplementary figure 4C Skeletal muscle Myosin

  7. -DKSDFITFGKKEEAKKLKKKKKKEKK-DK Dr|pcdh2ab12| -DKSDFITFGKKEEAKKLKKKKKKEKK-DK Dr|pcdh2ab5| -DKSDFITFGKKEEAKKLKKKKKKEKK-DK Dr|pcdh2ab3| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Gg|CNRv4| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Gg|CNRv7| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Gg|CNRv12| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Gg|CNRv8| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Gg|CNRv6| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Hs|PCDHA12| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Mm|Pcdha2| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Hs|PCDHA1| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Mm|Pcdha1| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Hs|PCDHA5| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Mm|Pcdha5| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Hs|PCDHA3| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Mm|Pcdha3| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Hs|PCDHA4| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Mm|Pcdha4| IQQIFFLIK--------------------- Hs|PCDHA9| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Hs|PCDHA7| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Mm|Pcdha8| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Mm|Pcdha7| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Mm|Pcdha12| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Hs|PCDHA13| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Hs|PCDHA10| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Hs|PCDHA2| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Mm|Pcdha9| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Mm|Pcdha6| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Hs|PCDHA8| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Hs|PCDHA6| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Hs|PCDHA11| IDKSDFITFGKKEETKKKKKKKKGNKTQEK Mm|Pcdha11| Supplementary figure 4D Protocadherin

  8. A B Percent genes expressed Relative expression 0 20 40 60 80 100 0 2 4 6 Excretion Excretion Circulation Circulation Skeleton Skeleton Neuronal Neuronal Respiration Respiration Reproduction Reproduction Sensory organs Sensory organ Digestion Digestion Immune System Immune Developmental Developmental SARPs SARPs Non- SARPs Non-SARPs Supplementary figure 5A & B

  9. C Orphan SARPs Familial SARPs 100 80 60 Percent genes expressed 40 20 0 Immune Skeleton Neuronal Excretion Digestion Circulation Respiration Reproduction Developmental Sensory organs Supplementary figure 5C

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