Ion channels defined
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Ion Channels defined. Literature Grows. Early Models. KcsA K channel structures. Gulbis structure. 3 Kinds of nervous signal. AP recording. HH AP. Single Na Channels. State diagram for Na Ch. Early Models. Ion channel disease 1. Ion channel disease 2. Ionic current moving ions.

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Ion Channels defined

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Ion Channels defined


Literature Grows


Early Models


KcsA K channel structures


Gulbis structure


3 Kinds of nervous signal


AP recording


HH AP


Single Na Channels


State diagram for Na Ch


Early Models


Ion channel disease 1


Ion channel disease 2


Ionic current moving ions


Ludwig Boltzmann

Question:

How is the internal energy in a system containing a large number of particles (N) distributed among the particles?

Ans.:there will be more particles with low energy (U) than with high

Boltzmann constant

(R/Na )

N

N(U) = A exp -(U/ kbT)

n1

n2

U

U1

U2


Biophysics: Nernst Potential


Current-Voltage Relations

E is potential in volts


Membrane Capacitance


Equivalent Circuits


AP recording


Flux coupling in a long pore

Force


KcsA K channel structures


Na:K ATPase, a Stoichiometric Transporter

Moves 3Na+ out and 2K+ in per ATP.

Stoichiometry of a pump


Evolutionary tree


K Channel Dendrogram


Three Roles of ion channels


Electrical call to action


Ca channel modulation


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