Ion channels defined
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Ion Channels defined. Literature Grows. Early Models. KcsA K channel structures. Gulbis structure. 3 Kinds of nervous signal. AP recording. HH AP. Single Na Channels. State diagram for Na Ch. Early Models. Ion channel disease 1. Ion channel disease 2. Ionic current moving ions.

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Ion Channels defined

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Ion Channels defined

Literature Grows

Early Models

KcsA K channel structures

Gulbis structure

3 Kinds of nervous signal

AP recording


Single Na Channels

State diagram for Na Ch

Early Models

Ion channel disease 1

Ion channel disease 2

Ionic current moving ions

Ludwig Boltzmann


How is the internal energy in a system containing a large number of particles (N) distributed among the particles?

Ans.:there will be more particles with low energy (U) than with high

Boltzmann constant

(R/Na )


N(U) = A exp -(U/ kbT)






Biophysics: Nernst Potential

Current-Voltage Relations

E is potential in volts

Membrane Capacitance

Equivalent Circuits

AP recording

Flux coupling in a long pore


KcsA K channel structures

Na:K ATPase, a Stoichiometric Transporter

Moves 3Na+ out and 2K+ in per ATP.

Stoichiometry of a pump

Evolutionary tree

K Channel Dendrogram

Three Roles of ion channels

Electrical call to action

Ca channel modulation

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