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THE MECHANICAL STABILITY OF ALLODERM  FOR MYRINGOPLASTY

THE MECHANICAL STABILITY OF ALLODERM  FOR MYRINGOPLASTY. Ian Scott Medical Biophysics April 7 th , 2010. The Middle Ear. The function of the middle ear is to transfer acoustic energy from air in the ear canal to the fluid within the cochlea. Myringoplasty.

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THE MECHANICAL STABILITY OF ALLODERM  FOR MYRINGOPLASTY

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  1. THE MECHANICAL STABILITY OF ALLODERM FOR MYRINGOPLASTY Ian Scott Medical Biophysics April 7th, 2010

  2. The Middle Ear The function of the middle ear is to transfer acoustic energy from air in the ear canal to the fluid within the cochlea

  3. Myringoplasty • Acute infections of the middle ear are extremely common, especially among children and infants • These infections can lead to perforations of the eardrum result of fluid and pressure build up • Myringoplasty or Type 1 tympanoplasty, is the reconstruction of the eardrum, and is a very common surgery occurring in 5.4/10,000 in a population

  4. Graft Materials • Autograft • Cartillage • Fascia • Allograft • Alloderm

  5. Advantages of AlloDerm • Decreased operating room time • Eliminates need for additional incisions • Decreased risk of morbidity • Allows for surgery when autologous tissue supply is exhausted • Revision myringoplasty surgeries are often required

  6. Alloderm • Acellular cadaveric tissue made by LifeCell Corp (Branchburg, NJ) • Treated with a decellularizing agent eliminating the possibility of rejection • Main structural components form a scaffolding

  7. Functional Requirements • Mechanically stable in presence of large pressures • Similar vibratory characteristics to the eardrum • Similar Young`s modulus and thickness to the eardrum

  8. Objective • Measure the response of AlloDerm to large static pressures up to 4kPa.

  9. Methods

  10. Results Fig. Pressure deformation curves for varying static pressures

  11. Results

  12. Discussion • AlloDerm showed stability up to 4kPa as required • Non-linear relationship shown between static pressure and deformation

  13. Conclusion • AlloDerm is stable up to 4kPa of applied static pressure • A non-linear relationship is shown between applied static pressure and deformation

  14. Future Work • Test on multiple samples to quantify variability in response • Measure the vibratory characteristics in application to sound transfer • Find Young`s modulus through the use of indentation tests to verify the required ``stiffness``

  15. Acknowledgements • Supervisor • Dr Hanif Ladak • Dr Sumit Agrawal • The Lab • Xiaochuan Ma • Govind Rehal

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