Countercurrent multiplication
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COUNTERCURRENT MULTIPLICATION. countercurrent multiplication refers to the ability of the kidney to increase the osmolality of the interstitium from the normal tissue value of 300 mosm/kg up to 1200-1400 mosm/kg this is necessary to allow the kidney to be able to concentrate the urine.

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COUNTERCURRENT MULTIPLICATION

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COUNTERCURRENT MULTIPLICATION

  • countercurrent multiplication refers to the ability of the kidney to increase the osmolality of the interstitium from the normal tissue value of 300 mosm/kg up to 1200-1400 mosm/kg

  • this is necessary to allow the kidney to be able to concentrate the urine


COUNTERCURRENT MULTIPLICATION

TIME 0

300

300

300

300

300

300

300


COUNTERCURRENT MULTIPLICATION

TIME 1

300

300

300

300

NaCl

500

100

200 mosm

300


COUNTERCURRENT MULTIPLICATION

TIME 2

300

300

NaCl

300

100

200 mosm

NaCl

500

300

200 mosm

500


COUNTERCURRENT MULTIPLICATION

TIME 3

300

100

NaCl

500

300

200 mosm

NaCl

700

500

200 mosm

500


COUNTERCURRENT MULTIPLICATION

TIME 4

NaCl

300

100

200 mosm

NaCl

500

300

200 mosm

NaCl

700

500

200 mosm

700


COUNTERCURRENT MULTIPLICATION

TIME 5

500

300

700

500

900

700

900


COUNTERCURRENT MULTIPLICATION

TIME 6

700

500

900

700

1100

900

1100


COUNTERCURRENT MULTIPLICATION

TIME 7

700

500

900

700

1100

900

1100


COUNTERCURRENT MULTIPLICATION

300

300

300

300

300

100

300

300

500

100

300

500

300

300

500

900

700

500

300

500

700

900

1100

700

500

900

700

500

700

900


COUNTERCURRENT MULTIPLICATIONTHE ROLE OF UREA

CD

Water

Water

urea

Loop


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