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COUNTERCURRENT MULTIPLICATION. countercurrent multiplication refers to the ability of the kidney to increase the osmolality of the interstitium from the normal tissue value of 300 mosm/kg up to 1200-1400 mosm/kg this is necessary to allow the kidney to be able to concentrate the urine.

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Countercurrent multiplication
COUNTERCURRENT MULTIPLICATION

  • countercurrent multiplication refers to the ability of the kidney to increase the osmolality of the interstitium from the normal tissue value of 300 mosm/kg up to 1200-1400 mosm/kg

  • this is necessary to allow the kidney to be able to concentrate the urine


Countercurrent multiplication1
COUNTERCURRENT MULTIPLICATION

TIME 0

300

300

300

300

300

300

300


Countercurrent multiplication2
COUNTERCURRENT MULTIPLICATION

TIME 1

300

300

300

300

NaCl

500

100

200 mosm

300


Countercurrent multiplication3
COUNTERCURRENT MULTIPLICATION

TIME 2

300

300

NaCl

300

100

200 mosm

NaCl

500

300

200 mosm

500


Countercurrent multiplication4
COUNTERCURRENT MULTIPLICATION

TIME 3

300

100

NaCl

500

300

200 mosm

NaCl

700

500

200 mosm

500


Countercurrent multiplication5
COUNTERCURRENT MULTIPLICATION

TIME 4

NaCl

300

100

200 mosm

NaCl

500

300

200 mosm

NaCl

700

500

200 mosm

700


Countercurrent multiplication6
COUNTERCURRENT MULTIPLICATION

TIME 5

500

300

700

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900

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900


Countercurrent multiplication7
COUNTERCURRENT MULTIPLICATION

TIME 6

700

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1100


Countercurrent multiplication8
COUNTERCURRENT MULTIPLICATION

TIME 7

700

500

900

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1100

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1100


Countercurrent multiplication9
COUNTERCURRENT MULTIPLICATION

300

300

300

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Countercurrent multiplication the role of urea
COUNTERCURRENT MULTIPLICATIONTHE ROLE OF UREA

CD

Water

Water

urea

Loop


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