1 / 10

The Renin-Angiotensin-Aldosterone System:

VBWG. The Renin-Angiotensin-Aldosterone System:. Linking New Data and Mechanisms for Cardiovascular Risk Reduction. VBWG. Contents. Scope of the problem Physiology of RAAS: Focus on angiotensin Role of RAAS modulation: Recent clinical trials CAD Diabetes ACEIs and ARBs

mahogany-spence
Download Presentation

The Renin-Angiotensin-Aldosterone System:

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. VBWG The Renin-Angiotensin-Aldosterone System: Linking New Data and Mechanisms for Cardiovascular Risk Reduction

  2. VBWG Contents Scope of the problem Physiology of RAAS: Focus on angiotensin Role of RAAS modulation: Recent clinical trials CAD Diabetes ACEIs and ARBs Management strategies for post-intervention in patients with CAD Appendix: Clinical guidelines

  3. VBWG Scope of the Problem

  4. VBWG Coronary artery disease: Leading cause of hospitalization in the US National bill (billions) Rank $66.2 AHA. Heart Disease and Stroke Statistics–2005 Update.

  5. VBWG Lifetime risk for CAD Framingham Heart Study Lifetime risk at age 40 Men Women 1 in 2 0.5 0.5 1 in 3 0.4 0.4 Cumulative risk of CAD 0.3 0.3 0.2 0.2 0.1 0.1 0 0 40 50 60 70 80 90 94 40 50 60 70 80 90 94 Age (years) Age (years) Lloyd-Jones D et al. Lancet. 1999;353:89-92.

  6. VBWG Multiple risk factors raise the risk for MI INTERHEART 333.7 512 182.9 256 128 68.5 42.3 Odds ratio for1st MI (99% CI) 64 32 13.0 16 8 3.3 2.9 4 2.4 1.9 2 1 Smk(1) DM(2) HTN(3) ApoB/A1(4) 1+2+3 1–4 All 4+obesity All 4+Psycho- social All Smk = smoking; DM = diabetes mellitus; HTN = hypertension; Apo = apolopoprotein Yusuf S et al. Lancet. 2004;364:937-52.

  7. VBWG Lifetime risk of diabetes for individuals born in 2000 Estimates based on National Health Interview Survey (1984–2000) 60 53 49 50 45 43 40 39 Lifetimerisk (%) 40 37 33 31 30 27 20 10 0 White Black Hispanic Other races/ethnicities Total* Men Women *Weighted race/ethnic-specific values by proportion of nondiabetic US population in 2000 Narayan KMV et al. JAMA. 2003;290:1884-90.

  8. VBWG Diabetes as a CHD risk equivalent: Impact on mortality in women and men N = 7052 men, 8354 women; age 45–64 yrs, follow-up 25 years Men Women 1.0 1.0 0.8 0.8 0.6 0.6 Survival rate 0.4 0.4 0.2 0.2 0.0 0.0 0 5 11 16 22 27 0 5 11 16 22 27 Years Years CHD Diabetes/CHD No Diabetes/CHD Diabetes Whiteley L et al. Diabetes Care. 2005;28:1588-93.

  9. VBWG Worldwide prevalence of diabetes expected to increase World Health Organization, 2000 vs 2030 Diabetes prevalence >171 million in 2000 ~366 million in 2030 140 +155% 120 120 100 +99% +102% Diabetes prevalence (in millions) 80 71 67 +44% +181% 60 48 47 42 40 36 +160% 33 33 18 20 15 7 0 W Pacific Africa Americas E Medit Europe SE Asia 2000 2030 www.who.int/diabetes/. July 2005.

  10. Over 1 million Americans will have an MI this year VBWG 500 410 400 372 New andrecurrentMIs(in thousands) 300 250 200 88 100 34 10 0 29–44 45–64 ≥65 Age (years) Men Women AHA. Heart Disease and Stroke Statistics–2005 Update.

More Related