Underestimating the burden of pertussis in wa 2011 cste annual meeting pittsburgh pa
This presentation is the property of its rightful owner.
Sponsored Links
1 / 29

Underestimating the burden of pertussis in WA 2011 CSTE Annual Meeting Pittsburgh, PA PowerPoint PPT Presentation


  • 81 Views
  • Uploaded on
  • Presentation posted in: General

Underestimating the burden of pertussis in WA 2011 CSTE Annual Meeting Pittsburgh, PA. Chas DeBolt RN, MPH Azadeh Tasslimi , MPH Washington State Department of Health. Objectives. Compare 2007-2010 PCR-positive suspect cases with confirmed pertussis cases to determine differences in:

Download Presentation

Underestimating the burden of pertussis in WA 2011 CSTE Annual Meeting Pittsburgh, PA

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Underestimating the burden of pertussis in wa 2011 cste annual meeting pittsburgh pa

Underestimating the burden of pertussis in WA 2011 CSTE Annual Meeting Pittsburgh, PA

Chas DeBolt RN, MPH

AzadehTasslimi, MPH

Washington State Department of Health


Objectives

Objectives

  • Compare 2007-2010 PCR-positive suspect cases with confirmedpertussis cases to determine differences in:

    • Demographics

    • Measures of severity, outcome & antibiotic use

    • Symptoms

  • Estimate sensitivity, specificity, & predictive value of Bordetellapertussis(Bp) PCR assays

    • WA State Public Health Laboratories (PHL), 2005-2010

    • Comparing results with standard culture


Case classification

Case classification*

Confirmed

  • Isolate Bp from clinical specimen +cough of any duration, OR

  • Detect Bp DNA by PCR + clinical case definition, OR

  • Link to lab-confirmed case + clinical case definition

    Probable

  • Meets clinical case definition but

    • No Bp isolation or Bp DNA detected by PCR AND

    • No link to a lab-confirmed case

* Only confirmed or probable cases reported to CDC


Case classification 2

Case classification (2)

  • Clinical case definition

    • Cough ≥ 2 weeks PLUSone of following

      • Cough paroxysms

      • Inspiratory “whoop”

      • Post-tussive emesis

  • Bp PCR in WA

    • 1999: Bp PCR implemented at PHL

    • By 2005, Bp PCR widely available at commercial labs


Bp culture pcr in wa

Bp Culture & PCR in WA

  • WA PHL, 2005-2010:

    • Of 9,623 samples sent for Bp culture, Bp isolated in only 318 (3.2%)

    • Of 5,369 samples sent for Bp PCR, Bp DNA detected in 422 (7.9%)

      • Of these, 4,468 (83%) also cultured

        • 99 PCR results uninterpretable

        • 4,372 with PCR result & culture result


Bp culture sample submissions to wa phl by year 2005 2010

BpCulture Sample Submissions to WA PHL by Year, 2005-2010

* Policy change at PHL to only receive samples whose testing result will be used to make public health decisions


Bp pcr sample submissions to wa phl by year 2005 2010

Bp PCR Sample Submissions to WA PHL by Year, 2005-2010

* Policy change at PHL to only receive samples whose testing result will be used to make public health decisions


Paired bp pcr culture results wa phl 2005 2010

Paired Bp PCR & culture results, WA PHL, 2005-2010

* Of these 12, 6 (50%) occurred during a single six-week period in Spring 2009


Performance of bp pcr performance compared to culture

Performance of Bp PCR performance compared to culture

  • Sensitivity: 87%

  • Specificity: 94%

  • PPV: 23%

  • NPV:100%


Changes in classification method for pertussis cases in wa

Changes in classification method for pertussis cases in WA

  • 2005: Web-based electronic reporting system (PHIMS) start-up in WA

  • Allows WA DOH & local health departments to jointly review/classify pertussis cases

    • Improved classification

  • 2005-2006: Many PCR-positive pertussis cases that do not meet clinical case definition


Wa doh defines suspect case

WA DOH defines “suspect” case

  • Person whose initial symptoms suggest pertussis

    • Subsequent testing negative OR no testing done

    • Cough duration < 2 weeks or cough duration undetermined


Wa doh establishes suspect case classification

WA DOH establishes “suspect” case classification

  • 2007: DOH defines Bp PCR-positive persons that do not meet clinical cases definitions as “suspect cases”*

  • No two-week cough in a PCR-positive person → “suspect”

  • For case & contact management, persons should be treated as if they had pertussis

  • Only confirmed & probable cases are reported to CDC

  • * http://www.doh.wa.gov/notify/guidelines/pdf/pertussis.pdf


Reported pertussis cases in wa 2007 2010

Reported pertussis cases in WA, 2007-2010

  • Confirmed cases:1466 (72%)

  • Probable cases: 375 (18%)

  • Suspect cases: 194 (10%)

    Among suspect cases, 81 (42%)

    Bp PCR-positive


Reported pertussis cases in wa by case classification 2007 2010

Reported pertussis cases in WA by case classification, 2007-2010

* Only confirmed or probable cases reported to CDC


Confirmed pcr positive suspect cases by age gender wa 2007 2010

Confirmed & PCR-positive suspect cases by age & gender, WA, 2007-2010


Confirmed pcr positive suspect cases by race ethnicity region of residence wa 2007 2010 wa

Confirmed & PCR-positive suspect cases by race, ethnicity & region of residence, WA, 2007-2010 WA


Comparing case defining symptoms clinical syndrome disease severity

Comparing, case-defining symptoms, clinical syndrome & disease severity

  • Case-defining symptoms (cough, whoop, vomit)

  • Clinical syndromes

    • Pneumonia

    • Encephalitis

  • Severity

    • Antibiotic received

    • ICU Admission

    • Hospitalized overnight

  • Case fatality ratio

  • Chronic lung disease in survivors


Comparison of case defining symptoms by case classification wa 2007 2010

Comparison of case-defining symptoms by case classification, WA, 2007 - 2010


Data completeness for clinically defining symptoms 2007 2010

Data completeness for clinically defining symptoms, 2007-2010


Comparison of syndrome outcome by case classification wa 2007 2010

Comparison of syndrome & outcome by case classification, WA, 2007-2010

* Fisher’s Exact Test, one-tailed


Data completeness by case classification 2007 2010

Data completeness by case classification, 2007-2010

*


Proportion of total number of confirmed pcr suspect cases by quarter of onset wa 2007 2010

Proportion of Total Number of Confirmed & PCR+ Suspect Cases by Quarter of Onset, WA, 2007-2010


Proportion of total number of confirmed pcr suspect cases by quarter of onset wa 2007 20101

Proportion of Total Number of Confirmed & PCR+ Suspect Cases by Quarter of Onset, WA, 2007-2010


Summary

Summary

  • Increasing use of Bp PCR since 2005

  • Bp PCR - 100% NPV for culture isolate

  • Of 194 suspect cases identified in WA in 2007-10, 81 (42%) associated with positive Bp PCR assay

  • PCR+ suspect & confirmed cases markedly different symptoms

    • May be due to incomplete data entry

  • PCR+ suspect & confirmed cases similar in

    • Age

    • Race/ethnicity

    • Geographic distribution

    • Clinical syndrome

    • Severity of illness

    • Outcome


Proposed actions

Proposed actions

  • If available, use Bp PCR result in algorithm to decide if culture should be pursued

  • Consider inclusion of PCR-positive cases as “probable cases” when 2-week cough, epidemiologic link, or association with an outbreak are not present

    • For discussion: PHL versus commercial lab results


Acknowledgements

Acknowledgements

Dr. Anthony A Tellez-Marfin, Washington State Department of Health

Ms. Yolanda Houze, Washington State Public Health Laboratories

Dr. Brendon “Troy” Leader, Washington State Public Health Laboratories

Health Officers and Disease Investigators of 35 WA State local health jurisdictions


Thank you questions

Thank you. Questions


Documentation of case defining symptoms for pcr positive suspect cases 2007 2010

Documentation of case-defining symptoms for PCR-positive suspect cases 2007-2010

  • 23/81 (28%) were missing data for at least one clinical case-defining variable

    • whoop, vomit, paroxysms, cough duration

  • For 17/81 (21%) the missing data were key to determining cases classification

    • 1 record missing all 4 clinical case defining criteria

    • 4 cases had a cough duration greater than 2 weeks but missing at least one of the other case-defining symptoms

    • 12 (15%) cases had at least one case-defining symptom, but were missing data for cough duration


Reported pertussis in wa state by case classification 2007 2010

Reported Pertussis in WA State by case classification 2007-2010


  • Login