DNA VIRUSES. DNA (genome) replication strategies similar in all and similar to host . ssDNA becomes dsDNA 5’ to 3’ synthesis; need for primer Variety of enzymes of host or viral origin : DNA polymerase (proofreading), helicases, ss binding proteins, ligases In nucleus except for poxviruses.
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Phage T4 replisome
This is now a template
DNA replication (polymerae,binding proteins, helicase/primase)
DNA repair proteins
Turn on Gamma/off Alpha
ICP27 - blocks host RNA splicing
Immune escape (MHC1 downregulation)
Turn on Beta genes