ARGENTINA AUSTRALIA BELGIUM BOTSWANA BRAZIL CAMBODIA CANADA CHILE CHINA COLUMBIA CZECH REPUBLIC

1. NIH SupportsBiomedical and Behavioral Research Around the GlobeIncluding Scientists at Institutions in over 90 Countries! KENYA LEBANON MALAWI MEXICO NETHERLANDS NEW ZEALAND NIGERIA PAKISTAN PERU POLAND RUSSIA SENEGAL SINGAPORE SOUTH AFRICA SPAIN SWEDEN SWITZERLAND THAILAND TURKEY UNITED KINGDOM URAGUAY ZIMBABWE AND MORE… ARGENTINA AUSTRALIA BELGIUM BOTSWANA BRAZIL CAMBODIA CANADA CHILE CHINA COLUMBIA CZECH REPUBLIC DENMARK DOMINICAN REPUBLIC EGYPT ESTONIA FINLAND FRANCE GERMANY HAITI HONG KONG HUNGARY ICELAND IRELAND ISRAEL ITALY JAPAN

2. Secretary of Health and Human Services Administration for Children and Families (ACF) Administration on Aging (AoA) Food and Drug Administration (FDA) Health Resources and Services Administration (HRSA) Center for Medicare & Medicaid Services (CMS) Agency for Healthcare Research and Quality (AHRQ) Indian Health Services (IHS) National Institutes of Health (NIH) Centers for Disease Control and Prevention (CDC) Agency for Toxic Substances and Disease Registry (ATSDR) Substance Abuse and Mental Health Services Administration (SAMHSA) U.S. Dept. of Health & Human Services

3. National Institutes of Health Office of the Director Office of Extramural Research National Institute on Aging National Institute on Alcohol Abuse and Alcoholism National Institute of Allergy and Infectious Diseases National Institute of Arthritis and Musculoskeletal and Skin Diseases National Cancer Institute National Institute of Child Health and Human Development National Institute of Dental and Craniofacial Research National Institute on Deafness and Other Communication Disorders National Institute of Diabetes and Digestive and Kidney Diseases National Institute on Drug Abuse National Institute of Environmental Health Sciences National Eye Institute National Institute of General Medical Sciences National Heart, Lung, and Blood Institute National Human Genome Research Institute National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Institute of NursingResearch National Center on Minority Health and Health Disparities National Institute of Biomedical Imaging and Bioengineering National Center for Complementary and Alternative Medicine Fogarty International Center National Center for Research Resources National Library of Medicine No funding authority NIH Clinical Center Center for Information Technology Center for Scientific Review

4. Grants Management Administrator The NIH Extramural Team The Research Partnership Applicant Institution NIH Program Administrator Principal Investigator Authorized Institutional Official Review Administrator Sponsored Research Administrator

5. NIH Initiatives and Hot Topics • NIH Themes • The B Word: NIH Budget and the impact of ARRA • Focus on New Investigators • Directions for Peer Review • Stem Cell Research • Assuring Objectivity in Research

6. Looking to the Future with theNew NIH Director To better understand the direction of NIH, here’s some known (and little known) facts about the leader of NIH: NIH Director as of August 17, 2009 Former Director of the National Human Genome Research Institute, NIH Leader of the Human Genome Project Dr. Collins’ own lab discovered a number of important genes, including those responsible for cystic fibrosis, neurofibromatosis, Huntington's disease and more. New York Times best selling book author Interest in the interface of science and faith. Musician and Rock Star of Science Believes the value of the NIH community is one where hard work, laughter, and compassion allow the imagination to soar. Francis S. Collins, Ph.D., MD

8. Opportunity 1: Using high throughput technologies to understand fundamental biology, and to uncover the causes of specific diseases

9. Opportunity 1: Using high throughput technologies to understand fundamental biology, and to uncover the causes of specific diseases • NextGen DNA sequencing and beyond • Nanotechnology • Small molecule screening • New imaging modalities • Emphasis on comprehensive approaches • All of the genes, all of the proteins, all of the common variations, all of the pathways for signal transduction, all of the patterns of gene expression, all of the steps in early development, all of the components of the immune system… • Computational biology is critical • Examples that are ripe for expanded effort • Cancer • Autism • Microbiome • Many more….

10. Opportunity #2: Translating basic science discoveries into new and better treatments Basic Research Drugs

11. Opportunity #2: Translating basic science discoveries into new and better treatments • Stage is set for NIH to play a greatly expanded role in translation • New discoveries about the fundamental basis of disease • Resources empowering academic investigators to develop lead compounds and “de-risk” projects • Opportunity for public-private partnerships • Stem cells (including hESC and iPSC) • Explosion of new information likely with new NIH policy – 64 cell lines now approved for federal funding • Therapeutic uses still uncertain but urgent to pursue • Small molecules • Roadmap provides high throughput screening (HTS) capabilities that now match that of many pharmaceutical companies • More on this theme later in the talk

12. Opportunity #3: Putting science to work for the benefit of health care

13. Opportunity #3: Putting science to work for the benefit of health care • Comparative effectiveness research • Prevention and personalized medicine • Behavioral research • Health disparities research • Pharmacogenomics • Large scale prospective studies • National Children’s Study • Study of adult onset diseases? • Health IT • Health research economics • Going beyond clinical trials to studying health care delivery in the real world? • What payment incentives actually work to reduce costs and improve outcomes?”