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TOXICOLOGY EDUCATION FACULTIES OF PHARMACEUTICAL SCIENCES PROF. W. LAMBERT GHENT UNIVERSITY (BE)

TOXICOLOGY EDUCATION FACULTIES OF PHARMACEUTICAL SCIENCES PROF. W. LAMBERT GHENT UNIVERSITY (BE). OVERVIEW. END TERMS OF STUDY BaMa STRUCTURE & COURSES « TOXICOLOGY » COURSE OVERVIEW OF CHAPTERS PRACTICAL EXERCISES / EXAMs « ILLICIT DRUG » COURSE

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TOXICOLOGY EDUCATION FACULTIES OF PHARMACEUTICAL SCIENCES PROF. W. LAMBERT GHENT UNIVERSITY (BE)

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  1. TOXICOLOGY EDUCATIONFACULTIES OFPHARMACEUTICAL SCIENCESPROF. W. LAMBERTGHENT UNIVERSITY (BE)

  2. OVERVIEW • END TERMS OF STUDY • BaMa STRUCTURE & COURSES • « TOXICOLOGY » COURSE OVERVIEW OF CHAPTERS PRACTICAL EXERCISES / EXAMs • « ILLICIT DRUG » COURSE • « ENVIRONM. TOXICOL. » COURSE • POSTACADEMIC EDUCATION • SITUATION AT OTHER UNIVERSITIES

  3. END TERMS OF STUDY • GENERAL & SOCIAL COMPETENCES COMMUNICATION CRITICAL INFORMATION ON MEDs INSIGHT IN SOCIAL & ETHICAL ASPECTS OF PHARMACY

  4. PHARMACEUTICAL KNOWLEDGE BASIC SCIENTIFIC PHARM / TECHNICAL APPLICATION PHARM / MEDICAL SCIENCES TO PHARM PROBLEM RATIONALIZED USE OF MEDs and PATIENT GUIDANCE RELATION PATIENT – MEDICATION - PHARMACIST KNOW / APPLY PHARMACOTHERAPY

  5. KNOWLEDGE OF INTERACTIONS , INCOMPATIBILITIES & SIDE EFFECTS OF MEDs • KNOWLEDGE OF QUALITY MONITORING OF MEDs

  6. BaMa STRUCTURE ’04-’05 1st BACHELOR 2nd BACHELOR 3rd BACHELOR BACHELOR OF SCIENCE (Pharm. Sciences) MASTER PROGRAM

  7. 1st BACHELOR ORGANIC CHEMISTRY 60 45 MATHEMATICS 22.5 30 PHYSICS 60 30 ANORG CHEMISTRY 60 45 ANATOMY & PHYSIOLOGY 45 ANIMAL BIOLOGY 30 22.5 PLANT BIOLOGY 30 15 DRUG DEVELOPM. & REPORT. 15 15 BASIC SCIENTIFIC KNOWLEDGE (80) PHARMACEUTICAL KNOWLEDGE (20) MEDICAL KNOWLEDGE SCIENTIFIC LITERATURE & REPORTING

  8. 2nd BACHELOR PHYTOCHEM & PHARMACOGNOSY 45 22.5 ANALYT. CHEM 45 120 PHARMACEUTICAL CHEM 30 BIOCHEM. & BIOPHYSICS 67.5 45 DISEASES 30 PHYSIOLOGY & PATHOPHYSIOLOGY 45 7.5 PHYSICOCHEM OF DRUGS 45 45 STATISTICS 15 30 PHARMACOKINETICS 22.5 7.5 BASIC SCIENTIFIC KNOWLEDGE (50) PHARMACEUTICAL KNOWLEDGE (50) MEDICAL KNOWLEDGE SCIENTIFIC RESEARCH (PRACTICAL EXERCISES)

  9. 3rd BACHELOR MEDICAL BIOCHEM 45 60 ANALYTICAL CHEM (INSTRUMENTAL) 45 75 PHARMACOLOGY 45 PHARMACOTHERAPY 15 PHARMACEUTICAL BIOTECHNOLOGY 45 15 MEDICINAL CHEMISTRY 45 15 PHARMACEUTICAL PREPARATIONS 45 60 PHARMACEUTICAL CASES 30 BASIC SCIENTIFIC KNOWLEDGE (20) PHARMACEUTICAL KNOWLEDGE (80) MEDICAL KNOWLEDGE SCIENTIFIC RESEARCH & PRACTICAL EXERCISES

  10. MASTER PROGRAM 1st MASTER 1st MASTER 2nd MASTER 2nd MASTER MASTER OF SCIENCE MASTER OF SCIENCE PHARM. CARE DRUG DEVELOPMENT PHARMACIST PHARMACY SCIENT. CARREER HOSPITAL PHARMACY INDUSTRIAL PHARM.

  11. MASTER PHARMACEUTICAL CARE « TRUNCUS COMMUNIS » WITH MASTER IN DRUG DEVELOPMENT 1st year 2nd year MICROBIOLOGY 45:60 PHARM TECH 30:90 BROMATOLOGY 37.5:60 TOXICOLOGY 45:60 PHARMACOTHER 30:- PHARM DEONT 15:- IMMUNOLOGY 10:- PHARM CARE & RAT. THESIS USE OF MEDs 30:- PRACTICE 6 M

  12. PHARMACO EPIDEMIOLOGY 10:-PHARMACO ECONOMICS 10:- & FREE CHOICE OF 4 + 2 COURSES 10:- : COMMUNICATION / PHARM INFORMATICS URGENT MEDICAL ASSISTANCE / MEDICAL DEVICES / PARASITOLOGY / DIET PRODUCTS / ILLICIT DRUGS / LAB. TESTS DIAGNOSIS / FOOD SECURITY DERMOPHARMACY / COSMETOLOGY / HOMEOPATHY / VETERINARY DRUGS

  13. MASTER DRUG DEVELOPMENT « TRUNCUS COMMUNIS » WITH MASTER IN PHARM CARE 1st year 2nd year MICROBIOLOGY 45:60 PHARM TECH 30:90 BROMATOLOGY 37.5:60 TOXICOLOGY 45:60 PHARMACOTHER 30:- PHARM DEONT 15:- IMMUNOLOGY 10:- PHARM CARE & RAT. THESIS USE OF MEDs 30:- PRACTICE 6 M

  14. ADVANCED DRUG ANALYSIS 20:30 & FREE CHOICE OF 3 + 3 COURSES 10:- : BIO-ANALYSIS / ADV. PHARM. BIOTECHNOL. ENZYMOLOGY / DRUG DESIGN MACROSCOP/MICROSCOP IMAGING INTROD. CLIN. STUDIES / ADV. BIOPHARM. MED LAB TECHNIQUES & IMMUNOCHEM DRUG REGISTRATION / ENVIRONM TOX. PHARMACOGENOMICS & PROTEOMICS

  15. CONTACT WITH TOXICOLOGY • TOXICOLOGY 45/60 « TRUNCUS COMMUNIS » 2nd MASTER • ILLICIT DRUGS 10/- FREE CHOICE (MASTER PHARM CARE) • ENVIRONMENTAL TOXICOL. 10/- FREE CHOICE (MASTER DRUG DEVELOPMENT)

  16. RELATION TO END TERMS • PHARMACEUTICAL KNOWLEDGE BASIC SCIENTIFIC PHARM / TECHNOLOGICAL • KNOWLEDGE OF INTERACTIONS, INCOMPATIBILITIES & SIDE EFFECTS OF MEDs • KNOWLEDGE OF QUALITY MONITORING OF MEDICATIONS

  17. TOXICOLOGY COURSE 45/60 • DEFINITIONS TOXICOLOGY HUMAN TOXICOLOGY FORENSIC CLINICAL OCCUPATIONAL ENVIRONMENTAL

  18. 2. ANALYTICAL TOXICOL. TECHNIQUES SAMPLE PREP : LLE SPE SCREENING : EMIT CHROMATOGRAPHY : TLC HPLC - DAD/MS GC - MS/NPD HEAD-SPACE GC RELEVANT IN LATER PARTS

  19. 3. TOXIC EFFFECTS TIME / LOCATION / TYPE • LOCAL – SYSTEMIC ACUTE – CHRONIC LATENT TEMPORARY – PERMANENT – CUMULATIVE • INFLAMMATION NECROSIS ENZYME INHIBITION LETHAL INCORPORATION LIPID PEROXIDATION

  20. COVALENT BINDING RECEPTOR INTERACTION HYPERSENSITIVITY IMMUNE SUPPRESSION CARCINOGENIC EFFECTS FOETOTOXICITY RELEVANT TOXICOLOGICAL DEFINITIONS

  21. 4. DOSE – RESPONSE CURVE DEFINITIONS & INTERPRETATION PARAMETERS THERAPEUTIC INDEX MARGIN OF SAFETY ACUTE LETHAL TOXICITY EFFICACY DERIVATION OF PROBIT DIAGRAM

  22. 5. TOXICOKINETICS OVERDOSE PHARMACOKINETICS ABSORPTION DISTRIBUTION METABOLISM ELIMINATION ADME CLINICAL IMPLICATIONS IN OVERDOSE CASES

  23. 6. BIOTRANSFORMATION PHASE – I – REACTIONS OXIDATION REDUCTION HYDROLYSIS EPOXIDE HYDROLYSIS PHASE – II – REACTIONS CONJUGATION ACETYLATION METHYLATION

  24. 7. BIOACTIVATION EXAMPLES ACETAMINOPHEN METHANOL CARBON TETRACHLORIDE BROMOBENZENE ISONIAZIDE* AROMATIC AMINES HALO ALKANES DIFFERENT MECHANISMS *GENETIC POLYMORPHISM ENZYME TRANSPORTER TARGET

  25. 8. AUTHENTIC FORENSIC CASES FATALITY BY CYP3A4 INHIBITION KETOCONAZOLE / TERFENADINE INTOXICATION BY SODIUM AZIDE INTERACTIONS CAPABILITIES & LIMITATIONS OF CHROMATOGR / SPECTROM TECHN

  26. 9. MEDICATIONS AND ILLICIT DRUGS PSYCHOLEPTICS PSYCHOANALEPTICS PSYCHODYSLEPTICS FOR EACH INDIVIDUAL COMPOUND WHAT ; ADME ; PHARMACODYNAMICS ; EFFECTS ; RISKS ; TREATMENT IN OVERDOSES ; ANALYTICAL ASPECTS

  27. a) PSYCHOLEPTICS • ETHANOL + ANALYTICAL ASPECTS • BARBITURATES • OPIATES MORPHINE - HEROINE PETHIDINE METHADON - BUPRENORPHINE + EFFECT ON NEUROTRANSMISSION + TREATMENT ADDICTION / OVERDOSE

  28. HYPNOTICS / SEDATIVES METHAQUALONE MEPROBAMATE BENZODIAZEPINES + MECHANISM AT RECEPTOR + GABA + FLUMAZENIL

  29. SOLVENTS ABUSED SOLVENTS SOLVENTS IN WORKING PLACE BENZENE TOLUENE CARBON DISULFIDE HEXANE + BIOMARKERS OF EXPOSURE

  30. b) PSYCHOANALEPTICS • COCAINE + TREATMENT OF ADDICTION CATALYTIC AB PARTIAL AGONISTS • AMPHETAMINES • MDMA & ANALOGS (MDEA PMA MTA) • NICOTINE • CAFEINE (EU/BE GUIDELINES) • KHAT

  31. c) PSYCHODYSLEPTICS • CANNABINOIDS • LSD • TRYPTAMINES SAME ASPECTS AS ABOVE

  32. 10. CARBON MONOXIDE SOURCES KINETICS EFFECTS ANALYTICAL ASPECTS TREATMENT OF INTOXICATION 11. CYANIDES SOURCES KINETICS EFFECTS ANALYTICAL ASPECTS TREATMENT OF INTOXICATION

  33. 12. PESTICIDES • ORGANOPHOSPHATES + MECHANISM OF ACTION / EFFECTS + TREATMENT • CARBAMATES • ORGANOCHLORINE DERIVATES • PYRETHRUM INSECTICIDES • HERBICIDES 2,4-D 2,4,5-T MCPA • PARAQUAT - DIQUAT + MECHANISM TOXICITY /TREATMENT

  34. PRACTICAL EXERCISES • QUANTITATION OF ETHANOL • EXTRACTION OF DRUGS / MEDs LLE / SPE • TLC OF DRUGS / MEDs • IDENTIFICATION UNKNOWN DRUGS • DEMONSTRATIONS EMIT / AAS / HPLC GC - MS / CO • PRESENTATION BY FED. POLICE ILLICIT DRUGS

  35. EXAMINATION • PRACTICAL EXERCISES PERMANENT (ORAL) AT THE END (BY WRITING) • THEORY AT THE END (BY WRITING) • RATIO IN FINAL QUOTATION 4 / 16

  36. ILLICIT DRUGS COURSE 10/-FREE CHOICE MASTER PHARM CARE • DEFINITIONS NEURONAL & SYNAPTIC TRANSM. AGONIST / ANTAGONIST • RELEVANT GROUPS OPIATES ; ANTIDEPRESSANTS STIMULANTS ; PSYCHEDELICS CANNABINOIDS ; SMART DRUGS • EXAMINATION AT THE END ( BY WRITING )

  37. ENVIRONM. TOX. COURSE 10/- FREE CHOICE MASTER DRUG DEVEL. • DEFINITIONS ENVIRONM CHEM / TOXICOLOGY ECOTOXICOLOGY BIOACCUMULATION • SPECIFIC GROUPS VOC’s PAH’s PCB’s • EXAMINATION AT THE END ( BY WRITING )

  38. POSTACADEMIC COURSE FOR JUDICIAL EXPERTS (UGent) • TYPES OF EXPERTISES • PROCEDURES BY EXPERTISES • DEONTOLOGY • CRIMINAL LAW • INSURANCE LAW • SOCIAL LAW • COURSES OF 3 HOURS START ’99 – ’00 (180 stud) ; ’01 – ’02 (100)

  39. ADDITIONAL TECHNICAL EDUCATION FOR JUDICIAL EXPERTS • VETERINARY EXPERTISES • FORENSIC & DNA EXPERTISES • ECOLOGICAL EXPERTISES

  40. PROGRAM AT KUL (LEUVEN) BaMa PHARMACEUTICAL CARE DRUG DEVELOPMENT • TOXICOLOGY I (40 h, TRUNC. COMM.) CONTENT SIMILAR AS UGent • TOXICOLOGY II (15 h, FREE CHOICE) TOXICITY OF INDUSTRIAL PRODUCTS • TOX. OF FYTOPHARMACEUT. PRODUCTS (15 h, FREE CHOICE)

  41. POSTACADEMIC COURSE MULTIDISCIPLINARY FORENSIC RESEARCH (KUL) • SESSIONS OF 3 h • BALLISTICS • FIRE & EXPLOSION FORENSICS • FORENSIC ACCOUNTANCY • CHILD ABUSE • DNA FORENSICS • TRAFFIC ACCIDENTS • FORENSIC TOXICOLOGY

  42. PROGRAM AT UA (ANTWERP) • TOXICOLOGY COURSE 45 h, 4th year SIMILAR CONTENT TO UGent LITTLE INFORMATION AVAILABLE NO POSTACADEMIC COURSE IN TOX.

  43. PROGRAM AT VUB (BRUSSELS) • TOXICOLOGY 45 h, 4th year PRACTICAL EXCERCISES 105 h • TOXICITY OF COSMETICS 15 h, 5th y. NO POSTCADEMIC COURSE IN TOX.

  44. CONCLUSION • BaMa PROGRAM SUFFICIENT TOXICOLOGICAL EDUCATION PROVIDED • POSTACADEMIC EDUCATION AT UgENT (yearly) AT KULeuven (yearly) PROBLEM : TARGET GROUP HAS IN MOST CASES ALREADY SEVERAL YEARS OF EXPERTISE

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