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INTRODUCTION. I. Cell Biology. A. Definition. B. History of Cell Biology. 1. Microscope Development. a. Zacharias Janssen , 1595 first light microscope. b. Galileo , 1609 focusing device. c. Robert Hooke , 1665 coined “ Cellulae”.

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INTRODUCTION

I. CellBiology

A. Definition

B.History of Cell Biology

1.Microscope Development

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a. Zacharias Janssen, 1595 first light microscope

b. Galileo, 1609 focusing device

c. Robert Hooke, 1665 coined “Cellulae”

d. Anton VanLeeuwenhoek, 1672 “Homunculus” and “Animalcules”

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e. Charles Spencer, 1850’s first compound scope

f. Max Knot & Ernst Ruska, 1933 first electron microscope

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a. Robert Dutrochet, 1824 plants made of cells

b. Robert Brown, 1824 Brownian motion & thenucleus

c. Theodor Schwann & Matthias Schleiden, 1839 Cell Theory

i. The cell is the basic unit in living organisms.

ii. The cell is the building block of organisms.

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d. J. Purkinji, 1840’s coined the term protoplasm

e. Rudolph Virchow, 1859 “Spontaneous Generation”

iii. Cells arise from preexisting cells.

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a. Karl VanNageli, 1846 plant cells derived from direct division of maternal cells

b. E. Strausburger & Walter Fleming, 1840’s directions for growth and division of cells contained in the nucleus

c. Gregor Mendel, 1860’s proposed a hereditary molecule was responsible for expression of traits in an organism

d. Frank Meischer, 1871 proposed nuclein material of nucleic acids

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d. Robert Altmann, 1889 purified nucleic acids into purine and pyrimidine bases DNA in all cells, while RNA variable

e. James Watson & Francis Crick, 1953 summarized research and built model of DNA

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II. Characteristics of Life

A. Highly Organized

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Bioenergetics

Figure 1.4

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Negative vs. PositiveMechanisms

Figure 1.12

Figure 1.11

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III. Types of Cells

A. Size Limits

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B. Prokaryotes

1.Size Limits

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C. Eukaryotes

1.Size Limits

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Figure 6.9

Figure 6.9

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D. Viruses

1.Characteristics

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The parts == protein (capsid , landing gear, and injector) surrounding a nucleic acid core (genome= can be DNA or RNA)

Figure 18.4

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