Thanks Genentech for Welcoming Roche Latin America to San Francisco

1. Thanks Genentech for Welcoming RocheLatin America to San Francisco

2. Pharma Medicines Leadership Team Pharma Medicines P. Soriot Global Product Develop.H. Barron/ SSF North America Comm OpsI. Clark / SSF Global Technical OpsP. Yang / Basel Western Europe Comm OpsP. Hug / Madrid Global Product StrategyD. Loew / Basel Asia Pacific Comm OpsL. Miels / Shanghai LatinAmerica Comm OpsJ. Rupp / Sao Paulo Global Portfolio MgmtSSF HR.M. Knierim / SSF CEMAI Comm OpsT. Göker / Basel FinanceP. Mongrolle / Basel Pharma Site Head BaselM. Baltisberger* * Not on MLT

3. Why are we here?Joerg Rupp - Regional Head Latin America To introduce LATAM to Genentech • Careers • Living in the region To help you understand why LATAM offers good career development To profile career opportunities in LATAM To discuss the skills and experiences that make people successful in LATAM To attract amazing US talent to the region To build on our common ambition to improve patients' lives

4. Latin America to San Francisco

5. Introduction Video

6. Latin America Region / Pharma Medicines Head Latin America Pharma Medicines Jörg-Michael Rupp Finance & SSCLuca Scavo Business DevelopmentMarcelo H. Santos Human ResourcesCarolyn Medley InformaticsVera Marques Colombia & EcuadorRolf E. Hönger Argentina & UruguayOsvaldo de la Fuente ChileRenê Delsin BrazilAdriano Treve Costa Rica (PRISA)Alvaro Soto VenezuelaLars Nielsen PeruPeter Braun MexicoMiguel Munera

7. Roche Latin America Overview Roche LA Affiliates & Sales** Total Sales: CHF 2.8 Bio Double-digit sales growth since 2002 Among Top 5 major companies in the total Latin American pharmaceutical market* ~ 4.000 employees; 1.400 Field Force Mexico & Brazil: In the top 10 for Roche and almost 58% of regional sales MostRoche companies present in LA for more than 70 years Top selling products 2010: MabThera, Herceptin, Avastin, Tamiflu, Rivotril Mexico (CHF 534 Mio) Venezuela (CHF 324 Mio) Central America & Caribbean (CHF 138 Mio) Colombia (CHF 228 Mio) Ecuador (CHF 48 Mio) Brazil(CHF 1`077 Mio) Peru (CHF 48 Mio) Uruguay(CHF 34 Mio) Chile(CHF 72 Mio) Argentina (CHF 269 Mio) * Estimates based on IMS Retail Audits + IMS Non-Retail Audits Brazil & Mexico / ** Estimated 2010 sales in CHF at average 2009 exchange rates

8. Why Latin America is a good choice for your Career Development? Entirely different work experience from the US Enhances your skills of dealing with uncertainty, the unexpected, and shifting priorities Gives you international experiences of dealing across multiple countries & Cultures Stretches your skills in leading a workforce that is incredibly diverse Latin America has developed a leadership pipeline that has enabled people to move to significant leadership roles in other parts of the world

9. Why Latin America is a good choice for your Career Development? Gives you the opportunity to work in emerging and growing markets It opens your eyes to entirely new environments - political, social and economic It develops your hands on generalist skills, whilst demanding high level strategic thinking Our regional business team offers demanding career opportunities because they act as the catalyst between HQ and the region. (The face of the region)

10. David LoewFrom Mexico to Europe

11. David Loew Testimonial Video

12. Regional Team Latin America Comercial Development Directo LAMarcelo H. Santos Training CoordinatorMárcia Cunha AssistantTatiana Oliveira Regional Strategic Planning Manager Bruno Vasques Regional Funding  Manager Stefan W. Weber Regional Marketing Manager, RA Raul Vivar (MEX) Regional Clinical Trial Manager, PA Anita Silva Regional Marketing Manager, Taspoglutide Juliana Pisani Regional Biosimilars Manager Vanessa Tubel Regional Marketing Manager, Oncology TBD Regional CRM Manager André Veloso Business Analyst Henrique Leite Marketing Analyst Kory Portela Marketing Analyst Maria C. Pinheiro Business Analyst Daniel Oliveira

13. Why the regional team? Enhances your communication and coordination skills because you will work across every market in the region Offers the unique opportunity to develop an understanding of an entire region. Requires leading and influencing colleagues in the region who do not report directly to you. Managing major international and regional events including Oncolatina and Rheumalatina High level of exposure to HQ A mini McKinsey talent development experience Track record of significant career moves out of this team to other parts of the Roche world

14. Cristina SouzaFrom the Regional Team to Switzerland HQ

15. Cristina Souza Testimonial Video

16. Brazil Fact Sheet Brazil affiliate & LATAM regional team collocated in Sao Paulo Manufacturing facility in Rio de Janeiro Over 1’000 people 36% of Roche LATAM sales World’s 10th largest economy Average GDP Growth 2005 – 2008 4.6% Population of 190 mio with 74% of population living above the poverty line Official Language Portuguese

17. Why Brazil? Diverse culture Top 10 Roche Market Highly dynamic environment Complex market with huge upside potential Regional dimension Exposure to high level senior management Ample opportunity for learning!! Rio de Janeiro Carnival!!

18. Duncan TrewFrom Mexico to Switzerland HQ

19. Duncan Trew Testimonial Video

20. Mexico Fact Sheet 21% of Roche LATAM sales Over 1’000 people Manufacturing facility 12th largest world economy Average GDP growth 2005 – 2008 3.25%.

21. Why Mexico? Proximity to the USA Tends to be more aligned to FDA decisions The taste of a different culture A career enhancing, cross-cultural commercial experience A stable and successful top team Top 10 Roche market Interesting projects because of emerging market status A wide range of products, franchises and business units Amazing beaches and Tequila!!

22. Dimitrios PapadopoulosFrom Switzerland HQ to Argentina

23. Dimitrios Papadopoulos Testimonial Video

24. Argentina Fact Sheet • 10% of Roche LATAM sales • Over 400 employees • Avergae GDP growth 2005 - 2008 8.3%. • Population of 41 mio with 86% of population above poverty line • Language: Spanish

25. Why Argentina? A blend of cultures – European, Arabic and Asian Quality of Life Index 2010 showed Argentina as the 26th best place to live in the world A challenging social and political environment that stretches your creative skills A very stable management team A mid size player in Latin America with a good share of voice in the region Strong internal investment and budgets especially in oncology The land of tango and great red wine

26. Max BucherFrom Costa Rica and Argentina to Switzerland HQ

27. Max Bucher Testimonial Video

28. Central America and The Caribbean Fact Sheet HQ: Costa Rica 4% of Roche LATAM sales Language: English & Spanish

29. Central America & The Caribbean A region within a region (23 countries) Complex geography Different regulatory environments Investment decisions Culturally & Ethnically Diverse. Cross cultural management Different Health Systems Flexibility Amazing Caribbean destinations.

30. Peter BraunFrom México to Switzerland HQ and Back to Perú

31. ’10 - General Manager ’06 –’10 Life Cycle Leader – Herceptin (Tarceva) Marketing & Sales Director ’03–’06 ’00–’03 Business Unit Head – Specialty ’99 MBA Intl Product Manager – Xenical ’97-’98 Product Manager - Oncology ’94-’97 ’92-’93 Business Trainee ’91-’92 Sales Representative Experiencie

32. Eric (8) & Nathalie (10) Danielle (wife) Mother / Father Additional Information Family Education • Undergrad • BA Arts – U. of Penn (College) • BA Sc in Econ – U. of Penn (Wharton) • Graduate • MBA - INSEAD Languages • English / Spanish • German • French • Dutch

33. Roche-Mexico - Oncology Product Manager • What did I offer? • Specific oncology knowledge (in mid-90s Roche was relatively new to field) • Analytical & organizational skills with strategic framework • Network in Basel Headquarters • Spanish fluency and familiarity with region allowed me to hit ground running • What did I learn? • Opportunity to gain broad marketing & sales experience quickly • Chance to “just do it” – apply analytical and organizational skills with focus on pragmatic solutions to drive business • Importance of people

34. Keys to success in operating in a foreign country Open mind to new environment and culture – Genuine interest in country and culture Quiet confidence but listen carefully (you can’t know it all!) Do not copy paste, previous experience and skills of high value but must be adapted to local situation Energy

35. So what do we expect from you if you come to LATAM? High level of integrity, passion and courage An open mind and the ability to be flexible in this unique environment A commitment to learning the culture and language To bring your knowledge and share it with your colleagues To be prepared to travel A desire to make a difference in Roche and patients' lives To bring innovative solutions to Latin America business challenges

36. International Assignments Long-Term Assignment duration: 1 – 5 years Usually part of the career development of high potentials Short-Term Assignment duration: 3 – 12 months Skill transfer/project work/trouble shooting Local to Local http://rochenet.roche.com/hr/hr-international_assignments/hr-international_assignment_policies.htm

37. Q&A

38. We Innovate Healthcare