1 / 37

Genital tract HPV types: LOW RISK: 6, 11, 40, 42, 43, 44;

Genital tract HPV types: LOW RISK: 6, 11, 40, 42, 43, 44; INTERMEDIATE RISK: 31, 33, 35, 51, 52; HIGH RISK: 16, 18, 45, 56. HPV-Induced Oncogenesis: Viral Events Integration at the E2 site leads to its deactivation and release of E6 and E7 gene inhibition.

lee-cline
Download Presentation

Genital tract HPV types: LOW RISK: 6, 11, 40, 42, 43, 44;

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Genital tract HPV types: LOW RISK: 6, 11, 40, 42, 43, 44; INTERMEDIATE RISK: 31, 33, 35, 51, 52; HIGH RISK: 16, 18, 45, 56

  2. HPV-Induced Oncogenesis: Viral Events Integration at the E2 site leads to its deactivation and release of E6 and E7 gene inhibition

  3. HPV-Induced Oncogenesis: Cellular Events E6 binds to p53 and induces its degradation. E7 binds the Rb gene product, causing the transcription factor E2F-1 to become unbound and free to induce cell cycle activation/growth.

  4. This algorithm generally depicts standard management options for abnormal Pap smears. Options include management of the first ASCUS smear and management of low-grade lesions (LGSIL). Atypical glandular cells of undetermined significance (AGCUS) should lead to consideration of colposcopy, endocervical curettage (ECC), and possibly cone biopsy (Bx).

More Related