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P ostdoctoral Research Project PNII-RU-PD-2012-3-0090 Contract No. 27/26.04.2013

P ostdoctoral Research Project PNII-RU-PD-2012-3-0090 Contract No. 27/26.04.2013. Silver nanoparticles - the effect of chemical surface modification on their chemical and biological reactivity Duration: 0 1 . 05.2013 – 30.05.2015. D irector of Project : Dr. Madalina Tudose.

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P ostdoctoral Research Project PNII-RU-PD-2012-3-0090 Contract No. 27/26.04.2013

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  1. Postdoctoral Research Project PNII-RU-PD-2012-3-0090 Contract No. 27/26.04.2013 Silver nanoparticles - the effect of chemical surface modification on their chemical and biological reactivity Duration: 01.05.2013 – 30.05.2015 Director of Project: Dr. Madalina Tudose Mentor of Project: Dr. Petre Ionita

  2. Project Budget

  3. Project Summary The challenge of this project is find out how different external chemical factors change the Ag NPs (bio)reactivity: What is the chemical nature of the Ag NPs surface (it is metallic, it is silver oxide, are silver ions absorbed on the surface?); and can be this nature changed by simple chemical treatments (i.e. reduction of silver oxide to metallic silver or vice versa). • The originality of such work is mainly related with the possibility to gain some types of robust and stable Ag or Ag@silica hybrid NPs, which can be chemically tuned to perform different types of reactions; besides these, factors affecting biological activity will be found and a manner to tune, increase or preserve such behavior will be also established. A mechanistic approach will be al well proposed. Those may have a high potential impact in (bio)materials science.

  4. Project Objectives 1. synthesis of several types of Ag NPs, by different chemical methods (using mainly ‘wet chemistry’), protected or not by different stabilizing ligands; 2. chemical surface modification of Ag NPs by different reagents; 3. studies regarding the effect of chemical modification on Ag NPs reactivity; 4. their use in catalytic (or not) oxidation and reduction processes; antioxidant or pro-oxidant evaluation; 5. coating the Ag NPs with silica for further organic derivatization (Ag@silica hybrid nanoparticles); 6. organic derivatization of hybrid nanoparticles, with compounds known to have antibacterial properties; 7. and finally, to evaluate their antimicrobial properties (biological evaluation).

  5. Dissemination of project results Papers in ISI Journals The Influence of Redox Chemical Surface Treatments on Silver Nanoparticles M. Tudose, C. Munteanu, G. Marinescu, D. Culita, P. Ionita submitted in Digest Journal of Nanomaterials and Biostructures , 2013.

  6. Dissemination of project results Conferences The influence of redox chemical surface treatment on silver nanoparticles M. Tudose, C. Munteanu, G. Marinescu, D. Culita, E. Hristea and P. Ionita ROMPHYSCHEM 15th edition: September 11-13, 2013, Bucharest, Romania

  7. Collaborations - Romanian Academy,’ C.D. Nenitescu’ Organic Chemistry Institute - National Institute for Materials Physics - University of Bucharest, Faculty of Biology - University of Bucharest, Faculty of Chemistry, Departments of Inorganic Chemistry, Organic and Physical Chemistry - Polytechnic University of Bucharest, Faculty of Applied Chemistry and Materials Science, Dept. of Organic Chemistry ‘C. Nenitescu’

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