1 / 11

Featured Article :

Featured Article :. Severe Hypoglycemia Identifies Vulnerable Patients With Type 2 Diabetes at Risk for Premature Death and All-Site Cancer: The Hong Kong Diabetes Registry.

lana-ramsey
Download Presentation

Featured Article :

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Featured Article: Severe Hypoglycemia Identifies Vulnerable Patients With Type 2 Diabetes at Risk for Premature Death and All-Site Cancer: The Hong Kong Diabetes Registry Alice P.S. Kong, Xilin Yang, Andrea Luk, Ronald C.W. Ma, Wing Yee So, Risa Ozaki, Rose Ting, Kitty Cheung, Chung Shun Ho, Michael H.M. Chan, Chun Chung Chow, and Juliana C.N. Chan Diabetes Care Volume 37: 1024-1031 April, 2014

  2. STUDY OBJECTIVE • To examine the associations of clinical profiles in type 2 diabetic patients who developed severe hypoglycemia and their clinical outcomes, including death and all-site cancer Kong et al. Diabetes Care 2014;37:1024-1031

  3. STUDY DESIGN AND METHODS • 8,767 type 2 diabetic patients with and without severe hypoglycemia in the 12 months before enrollment were recruited between 1995 and 2007, with follow-up until 2009 • Severe hypoglycemia was defined by ICD-9 codes as hospitalizations resulting from hypoglycemia • Cox proportional hazards regression was used to calculate the hazard ratio (HR) and 95% CIs of clinical factors collected at enrollment for severe hypoglycemia Kong et al. Diabetes Care 2014;37:1024-1031

  4. RESULTS • Mean age was 57.4 years • Median disease duration of diabetes was 5 years • During a median follow-up of 6.71 years, 235 patients had severe hypoglycemia • At enrollment, patients with and without severe hypoglycemia had similar cancer rates Kong et al. Diabetes Care 2014;37:1024-1031

  5. RESULTS • During follow-up, patients with severe hypoglycemia had a higher incidence of all-site cancer and mortality than those without severe hypoglycemia • Independent predictors for severe hypoglycemia: • • Old age • • Low BMI • • High glycated hemoglobin • • Low triglyceride (TG) • • Low LDL cholesterol • • Albuminuria • • Chronic kidney disease Kong et al. Diabetes Care 2014;37:1024-1031

  6. CONCLUSIONS • In type 2 diabetes, severe hypoglycemia is associated with advanced age, renal dysfunction, poor glycemic control, and cancer subphenotypes (low BMI, low • LDL cholesterol, and low TG) Kong et al. Diabetes Care 2014;37:1024-1031

  7. Kong et al. Diabetes Care 2014;37:1024-1031

  8. Kong et al. Diabetes Care 2014;37:1024-1031

  9. Kong et al. Diabetes Care 2014;37:1024-1031

  10. Kong et al. Diabetes Care 2014;37:1024-1031

  11. Kong et al. Diabetes Care 2014;37:1024-1031

More Related