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Metabolism of lipid

Metabolism of lipid. 1. summarize. • characteristics. • classification. • nomenclature. • essential fatty acid for nutrition purpose. • physiological functions. 2. digestion & absorption. • in the small intestine. • need bile salt .

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Metabolism of lipid

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  1. Metabolism of lipid 1.summarize •characteristics • classification

  2. • nomenclature

  3. • essential fatty acid for nutrition purpose

  4. • physiological functions

  5. 2. digestion & absorption • in the small intestine • need bile salt

  6. • the characteristics of lipid digestion

  7. 3. the transportation of lipids in blood stream ( lipoprotein)

  8. • the components & contents a. the kinds

  9. 甘油三酯 磷脂酰胆碱 磷脂酰乙醇胺 磷脂 神经鞘磷脂 游离胆固醇 血脂 胆固醇酯 胆固醇 酯化脂肪酸 脂肪酸 半酯化脂肪酸

  10. b. The importance

  11. • lipoprotein concept components & classification

  12. according the behavior of • electrophoresis or density • centrifugation

  13. 电泳法 乳糜微粒 前B-脂蛋白 B-脂蛋白 a-脂蛋白 电泳位置 原 a2球 B-球 a球 密度法 CM VLDL LDL HDL 密度 颗粒大小 +++ + + ++++ TG 胆固醇 + ++ +++ +++ 磷脂 + ++ ++ 生成部位 肠 肠、肝 血浆 肝、肠 功能 运输胆固醇到全身 运输内源TG 运输全身胆固醇到肝 运输外源TG

  14. b. the structure of lipoprotein

  15. c. apolipoproteins concept kinds synthetic site function

  16. • the function & metabolism of lipoprotein in blood

  17. a. CM synthesis transportation function metabolism

  18. capillary CM mature CM hydrolyze TG in CM ApoC-Ⅱ ApoE activated （activated （recognized LPL of LPL ) by CMR recept) FA HDL CMR liver return ApoC- Ⅱ

  19. characteristics b. VLDL synthesis transportation function metabolism

  20. LPL activated VLDL hydrolysis TG in VLDL ApoC-Ⅱ ApoE FA utilization ApoC-Ⅱ、 cholesterol or storage lecithoid in extrahepatic tissues HDL IDL cholesterol ester LDL（ rich of ester cholesterol)

  21. characteristics c. LDL synthesis characteristics function metabolism

  22. LDLin blood LDL receptor in tissue Recognized & binded by ApoB,E in LDL entered into tissue lysosome enzyme ApoB、 E break down cholesterol fatty acid

  23. Cholesterol in cell: Utilized control of metabolism of cholesterol Lack of LDL receptor ----- familial hypercholesterolemia

  24. d. HDL synthesis function metabolism

  25. LCAT in blood Liver HDL HDLin blood CH in HDL cell （ApoA、E、 （dishing） esterify C、D） （ CH、lecithoid） ApoC、E ApoC- Ⅱ CM、VLDL HDL synthesized mature HDL in intestine （globular） C CE IDL taken by liver

  26. Function of HDL 3 points

  27. hyperlipoproteinemia concept the primary affection （ receptor,enzyme,Apo) the secondary affection (diabetes,liver,kidney,thyroid fatness)

  28. 高脂血症 概念：空腹胆固醇>6mmol/L TG>2.26mmol/L 高脂血症=高脂蛋白血症 脂类代谢异常 高脂血症 心血管疾病 LDL、胆固醇 与动脉硬化 正相关 HDL 与动脉硬化 负相关 （保护因子） 如LDL HDL 则危险性

  29. 4. Intermediately metabolism of TG • catabolism of TG

  30. a. mobilization of TG concept characteristics

  31. limited enzyme triglyceride lipase ( hormone sensitive lipase)

  32. 1) lipolytic hormone 2) antilipolytic hormone (insulin)

  33. b. Oxidative catabolism of fattyacid characteristics

  34. • -oxidation a. evidence

  35. Even carbon atoms β α C6H5-CH2-CH2-CH2-CH2-CH2-CH2-CH2-COOH C6H5—CH2-COOH（苯乙酸）+Gly (苯乙尿酸)

  36. Odd carbon atoms β α C6H5-CH2-CH2-CH2-CH2-CH2-CH2-COOH C6H5—COOH（苯甲酸）+Gly ( 马尿酸)

  37. b. preparation 1) activation of fatty acid substrate: cofactors: enzyme: reaction site :

  38. Product: fatty acyl-CoA Process:

  39. 2) transported into mitochondria the carrier-------carnitine enzyme:

  40. the formula of carnitine （CH3）3-N-CH2-CH-CH2-COOH OH

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