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Lipid Metabolism

Lipid Metabolism. Lipid Metabolism. Lipid Metabolism. Lipid Metabolism. Digestion - Hydrolysis Reaction. Lipid Metabolism. Lipid Metabolism. Fatty Acid Oxidation. Initial Step: Requires an ATP to synthesize acetyl CoA with the fatty acid. Beta Oxidation. Beta Oxidation. Beta Oxidation.

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Lipid Metabolism

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  1. Lipid Metabolism

  2. Lipid Metabolism

  3. Lipid Metabolism

  4. Lipid Metabolism • Digestion - Hydrolysis Reaction

  5. Lipid Metabolism

  6. Lipid Metabolism

  7. Fatty Acid Oxidation • Initial Step: Requires an ATP to synthesize acetyl CoA with the fatty acid.

  8. Beta Oxidation

  9. Beta Oxidation

  10. Beta Oxidation

  11. Beta Oxidation

  12. Beta Oxidation

  13. Beta Oxidation

  14. Beta Oxidation

  15. Palmitic Acid Review

  16. Palmitic Acid -ATP Synthesis • Palmitic Acid is C-16 • Initiating Step - requires 1 ATP (text says 2) • Step 1 - FAD into e.t.c. = 2 ATP • Step 3 - NAD+ into e.t.c. = 3 ATP • Total ATP per turn of spiral = 5 ATP • Example with Palmitic Acid = 16 carbons = 8 acetyl groups • Number of turns of fatty acid spiral = 8-1 = 7 turns • ATP from fatty acid spiral = 7 turns and 5 per turn = 35 ATP. • NET ATP from Fatty Acid Spiral = 35 - 1 = 34 ATP

  17. Palmitic Acid (C-16) -ATP Synthesis • NET ATP - Fatty Acid Spiral = 35 - 1 = 34 ATP • Review ATP - Citric Acid Cycle start with Acetyl CoA • Step ATP produced • 7 visible ATP 1 • Step 4 (NAD+ to E.T.C.) 3 • Step 6 (NAD+ to E.T.C.)   3 • Step10 (NAD+ to E.T.C.)  3 • Step 8 (FAD to E.T.C.) 2 •  NET12 ATP per turn C.A.C. • 8 Acetyl CoA = 8 turns C.A.C. • 8 turns x 12 ATP/C.A.C. = 96 ATP • GRAND TOTAL130 ATP

  18. Acetyl CoA

  19. Ketone Bodies

  20. Ketone Bodies

  21. Blood Glucose and Glucosuria

  22. Ketone Bodies

  23. Lipogenesis

  24. COMPILED BY MD. AREEFUL HAQUE B.Pharm (9th Batch) Dept. of Pharmacy, IIUC E-mail: areeful@gmail.com www.areefpharma.weebly.com

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