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Division of Bacterial, Parasitic and Allergenic Products

Division of Bacterial, Parasitic and Allergenic Products. Jay E. Slater, MD Director, DBPAP. Division of Bacterial, Parasitic and Allergenic Products (DBPAP). Merger (1999) of Division of Bacterial Products (DBP) and Division of Allergenic Products and Parasitology (DAPP) Leadership

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Division of Bacterial, Parasitic and Allergenic Products

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  1. Division of Bacterial, Parasitic and Allergenic Products Jay E. Slater, MD Director, DBPAP

  2. Division of Bacterial, Parasitic and Allergenic Products (DBPAP) • Merger (1999) of • Division of Bacterial Products (DBP) and • Division of Allergenic Products and Parasitology (DAPP) • Leadership • Drusilla Burns, PhD (Acting) 1999-2000 • Richard Walker, PhD 2000-2008 • Milan Blake, PhD 2008-2010

  3. Immediate Office of the Director Jay Slater, MD – Director Drusilla Burns, PhD _Deputy Director (Acting) Regulatory Staff Jennifer Bridgewater – Assoc. Dir. Regulatory Policy Tina Roecklein - Regulatory Coordinator 5 FTE Laboratory of Bacterial Polysaccharides Willie Vann, PhD – Chief Mustafa Akkoyunlu , PhD Margaret Bash, MD Wei Wang, PhD John Cipollo , PhD Daron Freedberg , PhD 16 FTE, 11 ORISE Laboratory of Respiratory and Special Pathogens Drusilla Burns, PhD - Chief Juan Arciniega, D Sci James Keller, PhD Tod Merkel, PhD Michael Schmitt, PhD 16 FTE, 7 ORISE Laboratory of Enteric and Sexually Transmitted Diseases Scott Stibitz , Ph.D. – Chief (Acting) Dennis Kopecko , PhD 7 FTE, 13 ORISE Laboratory of Mycobacterial Diseases & Cellular Immunology Sheldon Morris, Ph.D. – Chief Siobhan Cowley, PhD Karen Elkins, PhD 10 FTE, 9 ORISE Laboratory of Immunobiochemisty Ron Rabin, M.D. – Chief 9 FTE, 7 ORISE As of 15 September 2010 Division of Bacterial, Parasitic and Allergenic Products (DBPAP)

  4. Non-invasive, toxin producers Bacillus anthracis (Bordetella parapertussis) Bordetella pertussis (Clostridium botulinum) Clostridium tetani Corynebacterium diphtheriae Invasive, protective responses to polysaccharides Haemophilus influenzae Neisseria meningitidis Streptococcus pneumoniae Intracellular (Francisella tularensis) Mycobacterium tuberculosis Mycobacterium bovis Enteric (Campylobacter jejuni) Salmonella typhi (Salmonella typhimurium) (Shigella dysenteriae) Parasite (Plasmodium spp) Other/emerging (Yersinia pestis) (Staphylococcus aureus) Allergenic products (Probiotics) DBPAP regulatory/research portfolio

  5. Non-invasive, toxin producers Bacillus anthracis (Bordetella parapertussis) Bordetella pertussis (Clostridium botulinum) Clostridium tetani Corynebacterium diphtheriae Invasive, protective responses to polysaccharides Haemophilus influenzae Neisseria meningitidis Streptococcus pneumoniae Intracellular (Francisella tularensis) Mycobacterium tuberculosis Mycobacterium bovis Enteric (Campylobacter jejuni) Salmonella typhi (Salmonella typhimurium) (Shigella dysenteriae) Parasite (Plasmodium spp) Other/emerging (Yersinia pestis) (Staphylococcus aureus) Allergenic products (Probiotics) DBPAP regulatory/research portfolioBacterial Polysaccharides (LBP)

  6. Non-invasive, toxin producers Bacillus anthracis (Bordetella parapertussis) Bordetella pertussis (Clostridium botulinum) Clostridium tetani Corynebacterium diphtheriae Invasive, protective responses to polysaccharides Haemophilus influenzae Neisseria meningitidis Streptococcus pneumoniae Intracellular (Francisella tularensis) Mycobacterium tuberculosis Mycobacterium bovis Enteric (Campylobacter jejuni) Salmonella typhi (Salmonella typhimurium) (Shigella dysenteriae) Parasite (Plasmodium spp) Other/emerging (Yersinia pestis) (Staphylococcus aureus) Allergenic products (Probiotics) DBPAP regulatory/research portfolioEnteric and Sexually Transmitted Diseases (LESTD)

  7. Enteric and Sexually Transmitted Diseases (LESTD) • Stibitz • Molecular genetics of virulence and virulence-gene regulation in bacterial respiratory pathogens • Kopecko • Evaluate safety and utility of Salmonella typhi Ty21a as an oral vaccine delivery platform for expression of foreign antigens and delivery of anti-cancer therapies • Analyze pathogenesis of and immune responses to Campylobacter jejuni infection in humans • Evaluate the vaccine potential of inactivated enteric bacteria

  8. Non-invasive, toxin producers Bacillus anthracis (Bordetella parapertussis) Bordetella pertussis (Clostridium botulinum) Clostridium tetani Corynebacterium diphtheriae Invasive, protective responses to polysaccharides Haemophilus influenzae Neisseria meningitidis Streptococcus pneumoniae Intracellular (Francisella tularensis) Mycobacterium tuberculosis Mycobacterium bovis Enteric (Campylobacter jejuni) Salmonella typhi (Salmonella typhimurium) (Shigella dysenteriae) Parasite (Plasmodium spp) Other/emerging (Yersinia pestis) (Staphylococcus aureus) Allergenic products (Probiotics) DBPAP regulatory/research portfolioImmunobiochemistry (LIB)

  9. Immunobiochemistry (LIB) • Rabin • IFN- isoforms that mediate immunosuppression induced by the respiratory syncytial virus • Slater • Development and validation of a multiplex allergen extract potency assay • Endotoxins in allergen extracts

  10. Non-invasive, toxin producers Bacillus anthracis (Bordetella parapertussis) Bordetella pertussis (Clostridium botulinum) Clostridium tetani Corynebacterium diphtheriae Invasive, protective responses to polysaccharides Haemophilus influenzae Neisseria meningitidis Streptococcus pneumoniae Intracellular (Francisella tularensis) Mycobacterium tuberculosis Mycobacterium bovis Enteric (Campylobacter jejuni) Salmonella typhi (Salmonella typhimurium) (Shigella dysenteriae) Parasite (Plasmodium spp) Other/emerging (Yersinia pestis) (Staphylococcus aureus) Allergenic products (Probiotics) DBPAP regulatory/research portfolioMycobacterial Diseases and Cellular Immunology (LMDCI)

  11. Mycobacterial Diseases and Cellular Immunology (LMDCI) • Elkins • Understand innate immune responses to intracellular bacteria in general and LVS in particular, particularly facets with implications for safety and efficacy outcomes. • Define mechanisms by which vaccine-induced immune T cells provide protection against intracellular bacteria, and thus establish practical immune correlates • Morris • Characterization of novel vaccines and immunization strategies against TB • Development of assays to facilitate the assessment of TB vaccines • Cowley • Characterization of unique aspects of mucosal immune responses to intracellular pathogens. • Malaria program – collaboration with OBRR

  12. Non-invasive, toxin producers Bacillus anthracis (Bordetella parapertussis) Bordetella pertussis (Clostridium botulinum) Clostridium tetani Corynebacterium diphtheriae Invasive, protective responses to polysaccharides Haemophilus influenzae Neisseria meningitidis Streptococcus pneumoniae Intracellular (Francisella tularensis) Mycobacterium tuberculosis Mycobacterium bovis Enteric (Campylobacter jejuni) Salmonella typhi (Salmonella typhimurium) (Shigella dysenteriae) Parasite (Plasmodium spp) Other/emerging (Yersinia pestis) (Staphylococcus aureus) Allergenic products (Probiotics) DBPAP regulatory/research portfolioRespiratory and Special Pathogens (LRSP)

  13. Arciniega Development and refinement of potency and toxicity tests for bacterial vaccines Burns Bacterial toxin structure/function relationships Study of host response to immunization with anthrax and Staphylococcal aureus vaccines Keller Clostridial neurotoxin vaccine and antitoxin research Merkel Development of animal aerosol challenge models for pertussis, anthrax and disease caused by Staphylococcus aureus. Analysis of gene regulation in Bordetella pertussis Schmitt Characterization of iron transport systems of Corynebacterium diphtheriae Analysis of gene regulation in C. diphtheriae Respiratory and Special Pathogens (LRSP)

  14. LBP presenters • Willie F. Vann, PhD • John Cipollo, PhD • Mustafa Akkoyunlu, MD, PhD • Daron I. Freedberg, PhD • Wei Wang, PhD • Margaret C. Bash, MD

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