Yale-UCL Senior Scientist Lecture Series, 2011
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Yale-UCL Senior Scientist Lecture Series, 2011 Mark Marsh LMCB, MRC Cell Biology Unit & Department of Developmental Biology, UCL. School of Life and Medical Sciences. SLMS has 2,562 members of research and academic staff.

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Yale-UCL Senior Scientist Lecture Series, 2011

Mark Marsh

LMCB, MRC Cell Biology Unit & Department of Developmental Biology, UCL


School of life and medical sciences
School of Life and Medical Sciences

  • SLMS has 2,562 members of research and academic staff.

  • UCL was ranked 4th for medicine in the 2011 Guardian University guide.

  • UCL has one of England’s five Comprehensive Biomedical Research Centres.

  • UCL Partners is one of the UK’s five Academic Health Science Centres.

  • The Medical Research Council granted UCL the largest amount of funding and highest number of awards in 2008/2009.

  • In the 2008 Research Assessment Exercise, 70–80% of research in the Life and Medical Sciences was graded as 3* or 4*

  • SLMS boasts the UK’s strongest medical research grouping

    (research power score, RAE 2008)


Slms domains

BASIC

RESEARCH SCIENCE

POPULATION HEALTH

EXPERIMENTAL MEDICINE

DISCOVERY SCIENCE

EDUCATION

PARTNERSHIPS

KNOWLEDGE TRANSFER

SLMS domains

INFECT. / IMM. / INFLAM.

CARDIO

METABOLIC

REPRO & DEVELPMNT.

FRONTIER DISCIPLINES

NEUROSCI.

CANCER


Ukcmri uk centre for medical research and innovation
UKCMRI UK Centre for Medical Research and Innovation

  • A world-class centre for interdisciplinary medical sciences, research and innovation

  • Situated at the heart of a cluster of scientific excellence in central London

  • A partnership of four of the world’s leading medical research organisations:

    • Medical Research Council,

    • Cancer Research UK

    • Wellcome Trust

    • UCL

  • Bringing together two of the country’s leading centres of medical research:

    • National Institute for Medical Research

    • London Research Institute


Ucl faculty of life sciences division of biomedicine
UCL Faculty of Life Sciences Division of Biomedicine

  • Genetics, Evolution and Environment

  • Neuroscience, Physiology and Pharmacology

  • Structural and Molecular Biology

  • Cell and Developmental Biology

  • Laboratory for Molecular Cell Biology


Department of Neuroscience, Physiology & Pharmacology

Dept has an outstanding history of research on receptors, ion channels and synaptic transmission. Highest ranked UK Department for ‘World-leading research’ RAE2008 (UoA15)

http://www.ucl.ac.uk/npp/index.html

Cellular & Molecular

Neuroscience

Receptor/ channel/ transporter & signaling molecules:

Attwell, Beato, Cull-Candy, Dolphin, Farrant, Gibb, Kittler, Schoepfer, Sivilotti, Smart, Vergani.

Structure-function:

Millar, Sivilotti, Smart

Central synaptic transmission & glia:

Attwell, Cull-Candy, Beato, Sihra

Healthy/ diseased states (channelopathies, animal models)

Stanford, Sivilotti, Schoepfer, Smart


Department of Neuroscience, Physiology & Pharmacology(2)

Systems Neuroscience

Neural connectivity/ computation

Mysic-Flogel, Hausser, Silver

In vivo transfection/ optogenetics

Mysic-Flogel, Hausser, Sjostrom

Systems/ translational neuroscience of pain- London Pain Consortium

Fitzgerald, Dickenson, Wood

Linking cellular/ neural networks to behaviour

Hausser, Mysic-Flogel, Sjostrom, Yeo


Department of Neuroscience, Physiology & Pharmacology(3)

Cell signalling

  • G-protein coupled receptor signaling

  • Brown, Dolphin, Pitcher, Moss, Pedarzani, Stocker, Smart

  • Phospholipid-dependent & NO signaling

  • Cockcroft, Garthwaite

  • Signal transduction in cardiovascular and immune systems.

  • Willis, Hobbs

  • Autonomic control of respiration & CVS

  • Gilbey, Gourine, Ramage


Cell and Developmental Biology

Brings together more than 65 members of academic staff to study a wide range of cell and developmental problems.

This includes aspects of stem cell biology, early embryo development, neural development and evolutionary (evo-devo) topics

Major research themes

  • Centre for Stem Cell and Regenerative Medicine (Claudio Stern)

  • Zebrafish research community - one of Europe’s largest fish research facilities, studying many aspects of developmental biology (Steve Wilson)

  • Learning and Centre for Cell and Molecular Dynamic contains UCL’s core imaging facility and houses labs which study:

    • Wound healing (Becker)

    • Circadian clocks (Whitmore)

    • Neural Development (Salinas)

  • Neural development and spatial learning and memory studies include:

    • Cortical development (Parnavalas)

    • Wnt Signaling and synapse formation (Salinas)

    • Neural Crest (Major, Mirsky, Jessen)

    • Spatial memory and learning (O’Keefe)


Genetics, Evolution and Environment

GEE has several core strengths, including diversity, quantitative biology, genetics, healthy aging and graduate training.

Human Genetics and Human Evolution (UCL Genetics Institute)

Bradman; Povey; Thomas; Swallow; Maniatis; Ruiz-Linares; Balding; Plagnol; Jones; Wood; MacKay

Evolution of development

Telford; Bahler; Olivieri; Gems; Partridge; Smith; Lane; Wingler

Systems biology (UCL Systems Biology)

Bahler; Pomiankowski; Reuter; Schuster; Partridge; Gems; Lazaros; Olivieri

Biology of Ageing (Institute of Healthy Ageing)

Partridge; Gems; Foukas; Pearce; Schuster; Wingler

Evolutionary Genetics

Fowler; Partridge; Greig; Pomiankowski; Yang; Reuter; Mallet; Lane; Balding; Plagnol; Jones; Bahler; Thomas

Biodiversity and environmental biology (Earth Sciences)

Mallet; Day; Chatterjee; Goswami; Murrell; Telford; Pearson; Wotton; Wingler

Computational biology (R. A. Fisher Centre for Computational Biology, CoMPLEX)

Pomiankowski; Murrell; Maniatis; Thomas; Yang; Reuter; Balding; Plagnol; Chatterjee


Our strengths quantitative biology

Genetics, Evolution and Environment (2)

Our strengths: Quantitative Biology

R. A. Fisher Centre for Computational Biology

  • population genetics, quantitative genetics, statistical inference, phylogenetics, QTL, transcriptomics

    CoMPLEX

  • Interface maths/statistics/computation in life/medical sciences, mathematical modelling

    UCL Systems Biology

  • Coordinating and strengthening interdisciplinary systems biology research across UCL


Our strengths centres of excellence

Genetics, Evolution and Environment (3)

Our strengths: Centres of Excellence

UCL Genetics Institute

  • Applying bio-statistical and bio-informatic approaches to genetic research with a focus on clinical and human population genetics

    Institute of Healthy Ageing

  • Bringing together researchers working on the basic biology of ageing and those working to understand the causes of ageing-related diseases


Our strengths graduate training

Genetics, Evolution and Environment (4)

Our strengths: Graduate Training

CoMPLEX

  • Centre for Mathematics and Physics in the Life Sciences and Experimental Biology

    Doctoral Training Centre

  • 15-20 MRes+PhD students / annum

  • Funded by EPSRC, MRC, BHF, BBSRC, NERC

    Post-Doctoral Training Centre

  • Starting April 2011, in collaboration with University of Oxford and Microsoft Research


Structural and Molecular Biology

The Department is a member of the Institute of Structural Molecular Biology (ISMB), which links UCL Departments of Chemistry and Structural and Molecular Biology, and the School of Crystallography at Birkbeck College

Major research themes:

  • Bioanalytical Chemistry

  • Bioinformatics

  • Cell Signalling & Metabolic Regulation

  • Molecular Microbiology

  • Molecular Cell Biology

  • Structural Biology & Molecular Biophysics



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