1 / 11

Buruli Ulcer

Buruli Ulcer . Arwen Frick-Cheng Bio 402. What is Buruli Ulcer?. Infectious disease Characterized by the WHO as a Neglected Tropical Diseases (NTD) 14 NTD Widely disregarded by industrial nations. What is Buruli Ulcer?. Regions/People Affected. Tropical wetlands and rainforest

kairos
Download Presentation

Buruli Ulcer

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Buruli Ulcer Arwen Frick-Cheng Bio 402

  2. What is Buruli Ulcer? • Infectious disease • Characterized by the WHO as a Neglected Tropical Diseases (NTD) • 14 NTD • Widely disregarded by industrial nations

  3. What is Buruli Ulcer?

  4. Regions/People Affected • Tropical wetlands and rainforest • Mainly: West and Central Africa • Associated with bodies of stagnant water • The immunocompromised • The poor • Children

  5. Causative Agent • Mycobacterium ulcerans • Related to Tuberculosis, Leprosy Colonies of Mycobacterium ulcerans. http://www.public.asu.edu/~shaydel/research_002buruli.html

  6. Identification of Bacteria • Acid Fast Stain • Selective Culture • Histopathology • PCR Acid-fast stain of Mycobacterium ulcerans. http://www.who.int/buruli/information/diagnosis/en/index14.html

  7. Symptoms • Long latent period • Usually on exposed body parts • Four stages

  8. Virulence Factor • Toxin: Mycolactone • Immunosupressant • Necrosis

  9. Treatment • Antibiotic • Rifampicin • Surgical removal/amputation • Vaccination (BCG) • Alternatives • Heat treatment • French Clay • Topical nitrogen oxides • Will slowly heal on its own

  10. Effects • Heavy scarring • Contracture of limbs • Blindness • secondary infections

  11. References • Neglected Diseases Caused By Bacterial Infections. M. Bechtle, S. Chen and T. Efferth. Current Medicinal Chemistry, 2010, 17, 42-60 • Laboratory diagnosis of Buruli ulcer disease. Marcus Beissner, Karl-Heinz Herbinger & Gisela Bretzel. Future Science Group • MycolactoneInhibits Monocyte Cytokine Production by a Posttranscriptional Mechanism.Rachel E. Simmonds et al. J. Immunol. 2009;182;2194-2202

More Related