Buruli ulcer
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Buruli Ulcer. Arwen Frick-Cheng Bio 402. What is Buruli Ulcer?. Infectious disease Characterized by the WHO as a Neglected Tropical Diseases (NTD) 14 NTD Widely disregarded by industrial nations. What is Buruli Ulcer?. Regions/People Affected. Tropical wetlands and rainforest

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Buruli Ulcer

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Buruli ulcer

Buruli Ulcer

Arwen Frick-Cheng

Bio 402


What is buruli ulcer

What is Buruli Ulcer?

  • Infectious disease

  • Characterized by the WHO as a Neglected Tropical Diseases (NTD)

    • 14 NTD

    • Widely disregarded by industrial nations


What is buruli ulcer1

What is Buruli Ulcer?


Regions people affected

Regions/People Affected

  • Tropical wetlands and rainforest

    • Mainly: West and Central Africa

  • Associated with bodies of stagnant water

  • The immunocompromised

  • The poor

  • Children


Causative agent

Causative Agent

  • Mycobacterium ulcerans

  • Related to Tuberculosis, Leprosy

Colonies of Mycobacterium ulcerans.

http://www.public.asu.edu/~shaydel/research_002buruli.html


Identification of bacteria

Identification of Bacteria

  • Acid Fast Stain

  • Selective Culture

  • Histopathology

  • PCR

Acid-fast stain of Mycobacterium ulcerans.

http://www.who.int/buruli/information/diagnosis/en/index14.html


Symptoms

Symptoms

  • Long latent period

  • Usually on exposed body parts

  • Four stages


Virulence factor

Virulence Factor

  • Toxin: Mycolactone

    • Immunosupressant

    • Necrosis


Treatment

Treatment

  • Antibiotic

    • Rifampicin

  • Surgical removal/amputation

  • Vaccination (BCG)

  • Alternatives

    • Heat treatment

    • French Clay

    • Topical nitrogen oxides

  • Will slowly heal on its own


Effects

Effects

  • Heavy scarring

    • Contracture of limbs

    • Blindness

  • secondary infections


References

References

  • Neglected Diseases Caused By Bacterial Infections. M. Bechtle, S. Chen and T. Efferth. Current Medicinal Chemistry, 2010, 17, 42-60

  • Laboratory diagnosis of Buruli ulcer disease. Marcus Beissner, Karl-Heinz Herbinger & Gisela Bretzel. Future Science Group

  • MycolactoneInhibits Monocyte Cytokine Production by a Posttranscriptional Mechanism.Rachel E. Simmonds et al. J. Immunol. 2009;182;2194-2202


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