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Block 5

Block 5. CASE 5. Gabatino-Labra. CASE 5. Patient is a known schizophrenic maintained on Chlorpromazine 100 mg per orem 2x/day for 6 months . Two weeks prior to consult, he was prescribed Propranolol 40 mg/tablet 2 tablets 3x/day. QUESTION. What caused the symptoms of the patient?.

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Block 5

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  1. Block 5 CASE 5 Gabatino-Labra

  2. CASE 5

  3. Patient is a knownschizophrenic • maintained on Chlorpromazine • 100 mg per orem 2x/day for 6 months. • Two weeks prior to consult, he was prescribed Propranolol • 40 mg/tablet 2 tablets 3x/day.

  4. QUESTION • What caused the symptoms of the patient?

  5. Chlorpromazine

  6. Metabolism Chlorpromazine CYP 2D6 typically degraded by the liver by the action of cytochrome-P450 family enzymes, usually CYP2D6 • 7-hydroxylation

  7. Propranolol

  8. Metabolism Propranolol CYP 2D6 • aromatic hydroxylation 4-hydroxy propranolol is a weak inhibitor of CYP2D6

  9. Drug Interaction 70% Propranolol Chlorpromazine

  10. Drug Interaction

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