Influences on resistance. Neural/Humoral: all the same players as in the periphery (but less effective) and a few with more specific actionsSerotonin:Arterial side vasoconstrictionHistamine:Venular side vaso(veno)constriction ***venous side can become dominant resistanceIntravascular Pressure
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(relatively little smooth muscle)
Neural/Humoral: all the same players as in the periphery (but less effective) and a few with more specific actions
Serotonin: Arterial side vasoconstriction
Histamine: Venular side vaso(veno)constriction
***venous side can become dominant resistance
Intravascular Pressure R 1/P
Pulmonary Vascular Resistance
Arterial or Venous Pressure
***Thus, cardiac output is considered to be the primary determinant of pulmonary vascular resistance
Lung Volume (ml)
* Lung volume effects on extra-alveolar vessels is lost with positive pressure ventilation.
The Starling Resistor Concept
Left Atrial Pressure Tracing