Bone metabolism
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Bone Metabolism. Rickets. Rickets (children) – failure of mineralization of the epiphyseal plate Related to lack of Vitamin D Dietary Poverty Third world countries Sunlight exposure Northern latitudes Sun screen Metabolic failure. Renal Osteodystrophy.

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Bone Metabolism

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Bone metabolism

Bone Metabolism


Rickets

Rickets

  • Rickets (children) – failure of mineralization of the epiphyseal plate

  • Related to lack of Vitamin D

    • Dietary

      • Poverty

      • Third world countries

    • Sunlight exposure

      • Northern latitudes

      • Sun screen

    • Metabolic failure


Renal osteodystrophy

Renal Osteodystrophy

  • Osteomalacia (low bone density) – failure of mineralization of osteoid

  • Osteosclerosis (high bone density) – dense bones

    • Abnormal resorption of mineral

    • Abnormal deposition of mineral


Renal rickets

Renal Rickets

  • Child

  • Zone of provisional calcification is deficient

  • Metaphyses irregularly mineralized, widened and cupped

  • Fracture of distal fibula

Images courtesy Nancy Fitzgerald, MD, Texas Children’s Hospital


Rickets1

Rickets

  • Widening of the ribs at the costal-chondral junction

  • Known clinically as Rachitic Rosary


Rickets2

Rickets

Images courtesy Nancy Fitzgerald, MD, Texas Children’s Hospital


Rickets3

Rickets

  • Widened metaphysis with fraying


Rickets4

Rickets

  • Wrist film

  • Another patient

  • Cupping and fraying of metaphyses


Treated rickets

Treated Rickets

  • Same patient after 3 months of Vitamin D

  • Improved appearance with well defined slightly undulating metaphysis


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