Peanut Allergy: Natural History and Prospects for Treatment. Robert A. Wood, MD Professor of Pediatrics Director, Pediatric Allergy and Immunology Johns Hopkins University School of Medicine. Peanut Allergy - Overview. Common in both children and adults
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Robert A. Wood, MD
Professor of Pediatrics
Director, Pediatric Allergy and Immunology
Johns Hopkins University School of Medicine
Food Young ChildrenAdults
Milk 2.5% 0.3%
Egg 1.3% 0.2%
Peanut 0.8% 0.6%
Tree nuts 0.4% 0.4%
Fish 0.1% 0.4%
Shellfish 0.1% 2.0%
Overall 6.0% 3.7%
(VanderLeek et al J Peds 2001)
Studies on the Natural History of Peanut Allergy (Skolnick et al (JACI 2001;107:367)
84 additional patients, all with PN-IgE levels ≤ 5 at challenge
Children with PN-IgE levels ≤ 2 were significantly more likely to pass than those with levels between 2 and 5 (p<0.003)
(Fleischer et al, JACI 2005)
Effect of Anti-IgE Therapy in Patients with Peanut Allergy(Leung et al, NEJM 2003;348:986)
Dose of TNX-901
Chinese Herbal Formula (FAHF-1)
The Peanut Allergen Ara h 2
LTILVALALF LLAAHASARQ QWELOGDRRC QSQLERQNLR PCEQHLMQKI QRDEDSYERD
IgE Binding Site T Cell Binding Site
Stimulates T cells but does not bind to IgE – will not cause an allergic reaction
With this information, immunotherapy could be developed that only contains the relevant T cell binding segments
Sublingual Immunotherapy for Hazelnut Allergy (Enrique et al, JACI 116:1073, 2005)
Oral challenge tests: mean food amounts tolerated in patients with hazelnut SLIT and placebo SLIT before and after immunotherapy.
Present and Future Initiatives patients with hazelnut SLIT and placebo SLIT before and after immunotherapy.
Peanut Allergy - Summary patients with hazelnut SLIT and placebo SLIT before and after immunotherapy.