Non alzheimer s dementia
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Non Alzheimer’s Dementia. Kevin Overbeck, DO Assistant Professor UMDNJ –SOM NJISA . Non-Alzheimer’s Dementia. This medical student presentation is offered by the New Jersey Institute for Successful Aging.

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Non alzheimer s dementia

Non Alzheimer’s Dementia

Kevin Overbeck, DO

Assistant Professor


Non alzheimer s dementia

Non-Alzheimer’s Dementia

This medical student presentation is offered by the New Jersey Institute for Successful Aging.

This lecture series is supported by an educational grant from the Donald W. Reynolds Foundation Aging and Quality of Life program.

Learning objectives

Learning Objectives

  • Compare and contrast clinical features that distinguish vascular dementia, frontotemporal dementia, and Lewy body dementia

  • Differentiate between Alzheimer's disease and all other dementias

Prevalence of common dementias

Prevalence of Common Dementias

Image Source: Weiss BD. Elder Care: A Resource for Interprofessional providers. Accessed: October 5, 2011.

Evaluation of memory loss

Evaluation of Memory Loss

  • HPI (establish timeline and clinical presenting features)

  • Detailed MED review

  • CAM

  • GDS


  • Pertinent physical exam findings

  • LABs (BMP, CBC, LFTs, TSH, B12, Folate)

  • Brain imaging (CT Scan or MRI [MRI preferred])

  • Other considered studies – RPR, UDS, EtOH level, EEG, CXR, EKG, HIV

Evaluation of memory loss1

Evaluation of Memory Loss

Patient with Known or Suspected Memory Loss




Identify Underlying Cause of Delirium & Treat

No Delirium

Equivocal or Inconsistent with Depression

Consistent with Depression


Treat Depression or Discuss Options




Not Impaired

Re-evaluate After Treatment


Brain Imaging

No Action

Vascular dementia

Vascular Dementia

  • Onset of cognitive deficits with a stroke

  • Abrupt onset of symptoms with stepwisedeterioration

  • Often neurological exam findings consistent with a prior stroke

  • Infarcts on cerebral imaging

Vascular dementia1

Vascular Dementia

Hachinski Ischemic Index highlights clinical features

Scores > 7 suggest vascular dementia

Also of note: patients with vascular dementia are more likely to have impaired executive function than those with AD

Vascular dementia2

Vascular Dementia

  • HTN

  • DM

  • Statins

  • Aspirin

Frontotemporal lobe dementia ftd

Frontotemporal Lobe Dementia (FTD)

  • Atrophy of the frontal and temporal lobes

  • Absence of AD pathology

  • Clinically: personality, behavior & language problems

  • Impaired executive function

Non alzheimer s dementia


  • Ages 35-70 years

  • Rare after age 75

  • Familial occurrence in ~40% of cases

  • More rapidly progressive disorder than AD

  • Fatal Illness

Non alzheimer s dementia


  • Pick’s disease is a subtype of FTD but was the first described

  • Presence of Pick bodies (silver staining intracytoplasmic inclusion bodies)

Note: All FTD is associated with a serotonergic deficit and decreased dopaminergic activity has been described; acetylcholinesterase activity is relatively intact

Non alzheimer s dementia


  • Inappropriate social behavior (conduct)

  • <10% have short term memory impairment on testing @ initial presentation

  • Poor insight into their condition

  • Often mistaken for a psychiatric condition

Clinical Manifestations

Photo: Microsoft Office Images #MP900448297 by Fotolia (

Ftd a case

FTD: A Case

A 68 year old male presents to subacute rehabilitation following a fall and subdural hematoma. A diagnosis of FTD was made two years prior to the incident via neuropsychological testing.

Despite much improved mobility and function back to baseline, he was “made” long term care at a local nursing home, due to poor safety awareness (primarily concerns about wandering).

Admission MMSE 21/30 (deficits noted below)/abnormal CDT 2/4

  • 1/3 short term recall

  • 1/5 serial sevens

  • 0/1 pentagon

  • 8/10 orientation

Ftd a case1

FTD: A Case

“I want to see what I can do about getting out of here?” He would go to report that his wife is taking his money and “she’s trying to divorce me you know.”

Very often a visit from his wife (or a telephone call) was the only thing that could calm him down.

Other behaviors were collecting towels, poor hygiene.

Then… he ate my sandwich.

Non alzheimer s dementia


  • The FDA has not approved any drugs to treat this condition.

  • Memantine is presently being studied.

Ftd vs ad


Weiss BD. Elder Care: A Resource for Interprofessional providers. Accessed: October 5, 2011.

Lewy body dementia

Lewy Body Dementia

  • DLB is the 3rd most common dementia after AD

  • Progressive gradual dementia

  • Fluctuations in cognitive function

  • Persistent, well-formed hallucinations

  • Spontaneous motor features of parkinsonism

Lewy body dementia a case

Lewy Body Dementia: A Case

An 81 year old former PhD psychologist is transferred to assisted living from her independent living home due to significant increased deficits in her functional status – including multiple falls, inability to self-administer medications, a reversal of the sleep-wake cycle, and profound weight loss

  • Admission MMSE: 28/30 (+) deficit 3/5 serial sevens

  • Admission Weight: 108 lbs

    During the next four weeks there is stabilization of the sleep-wake cycle and weight gain (112 lbs)

Lewy body dementia a case1

Lewy Body Dementia: A Case

During the next year, despite several falls that responded to physical therapy she continues to need considerable more help dressing as well as orientation/cuing (i.e. meals and medication times). Observation from nursing is that she is just “lost” and even ostracized by other residents.

On two separate occasions she reported that she saw a mouse running across the ceiling. It was investigated in earnest but no evidence of mice could be found.

Lewy body dementia a case2

Lewy Body Dementia: A Case

She is transferred to a specialized dementia unit in which her behavior (now observed more closely) is vastly different than other’s with Alzheimer’s dementia.

One year later (+) cogwheel rigidity is noted.

Lewy body dementia1

Lewy Body Dementia

  • The FDA has not approved any drugs to treat this condition.

Lewy body dementia vs ad

Lewy Body Dementia vs. AD

Parkinson s disease dementia

Parkinson’s Disease Dementia

  • Estimated six-fold increased risk for becoming demented compared with people without the disorder.

  • Dementia typically occurs in the last half of the PD clinical course (whereas, in DLB, it’s the presenting feature)

  • Executive dysfunction is a hallmark feature

Parkinson s disease dementia1

Parkinson’s Disease Dementia

  • Rivastigmine (Exelon®) has been approved for use in mild-to-moderate Parkinson’s related dementia.

Normal pressure hydrocephalus nph

Normal Pressure Hydrocephalus (NPH)

  • “Classic Triad” of symptoms:

    • Dementia

    • Gait Disturbance

    • Urinary Incontinence

  • Pathologically enlarged ventricular size

  • Normal opening pressures on lumbar puncture

  • Potentially reversible by the placement of a ventriculoperitoneal shunt

Hiv associated dementia

HIV Associated Dementia

  • Age is a significant risk factor in HIV-associated dementia

  • Clinical Symptoms

    • Distractibility/Poor Concentration

    • Mood Changes/Apathy vs Lability

    • Gait Dysfunction/Clumsiness

    • Reduced psychomotor speed

  • Absence aphasia, agnosia, & apraxia (until late disease course) helps distinguish from AD

Huntington s disease hd

Huntington’s Disease (HD)

  • Huntington’s Disease - traced to emigrants (1630) from East Anglican village of Bures, England:

    - Dominant inheritance (1 parent with gene) - CAG

    - Choreoathetosis starting at 35-45 years of age

    - Dementia & emotional lability also

Creutzfeldt jakob disease

Creutzfeldt-Jakob Disease

  • Rapidly progressive dementia

  • Pathogenesis: Prions

  • Typically fatal within 1-2 years after symptom onset

  • Motor deficits & seizures often occur

  • Not treatable

  • Potentially transmissible

  • No clear cut MRI findings

Alcoholic dementia

Alcoholic Dementia

  • Alcoholic dementia

    • Cerebellar and corpus callosum atrophy

    • Affective prosody comprehension decline

    • Gait problems

    • Abstract reasoning decline more than education knowledge

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