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CogSci Projects for Spring 2005.

U. H. CogSci Projects for Spring 2005. Inter- and Intra-Individual Gating Differences. Ben H.Jansen Department of Electrical and Computer Engineering, and Center for Neuro-Engineering and Cognitive Science, University of Houston, Texas bjansen@uh.edu.

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CogSci Projects for Spring 2005.

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  1. U H

  2. CogSci Projects for Spring 2005.

  3. Inter- and Intra-Individual Gating Differences. Ben H.Jansen Department of Electrical and Computer Engineering, and Center for Neuro-Engineering and Cognitive Science, University of Houston, Texas bjansen@uh.edu Collaborators: Nashaat N Boutros, MD, Dept. Psychiatry, Yale U; Lingli Hu, Bharat Bonala, Karthik Sundaresan, Prashant Kota,Hitesh Doshi, Vijay Grandhi, Gopal Agarwal, Ruben Jacob, Anant Hegde, Darshan Iyer, Violet Garoosi Supported by NIH/NIMH R01 MH58784, NSF/REU and UH-GEAR

  4. P200 P50 mV 8 6 S1 S2 4 2 0 -100 -50 0 50 100 150 200 250 300 -2 ms -4 -6 stim N100 Sensory Gating Gating: ability to suppress irrelevant stimuli Double Stimulus Paradigm: • Two identical tone bursts 0.5 s apart • S1 response larger than S2

  5. 8 8 S1 S2 6 6 NC NC SZ SZ 4 4 2 2 0 0 -100 -50 0 50 100 150 200 250 300 -100 -50 0 50 100 150 200 250 300 -2 -2 -4 -4 -6 -6 Gating Deficits in Schizophrenia? mV mV ms ms

  6. 8.0s 0.5s • Double Clicks: • A: identical • B, C: non-identical • Trains: • F, G: S1=…=S5=S6 S1 S2 S1 S2 S1 S2 8.0s S1 … S5 S6 S1 … S5 S6 / Paradigms and Data Set • 16 normal subjects, 17 schizophrenia patients. • Max. 4 sessions/subject • Cz-linked ears, Artifacts removed • Paradigms:

  7. mV P200 A B C F G N100 NC SZ P50 S2 S2 S1 S2 S1 S1 S1 and S2 Grand Average Amplitudes: Paradigms

  8. 71 51 53 83 56 58 5 5 A 0 0 -5 -5 0 100 200 300 400 500 0 100 200 300 400 500 5 5 F 0 0 -5 -5 0 100 200 300 400 500 0 100 200 300 400 500 5 5 G 0 0 -5 -5 0 100 200 300 400 500 0 100 200 300 400 500 5 5 B 0 0 -5 -5 0 100 200 300 400 500 0 100 200 300 400 500 5 5 C 0 0 -5 -5 0 100 200 300 400 500 0 100 200 300 400 500 Gating in Normal Controls S1 S2 P50 N100 P200

  9. 831 72 73 91 85 80 5 5 A 0 0 -5 -5 0 100 200 300 400 500 0 100 200 300 400 500 5 5 B 0 0 -5 -5 0 100 200 300 400 500 0 100 200 300 400 500 5 5 C 0 0 -5 -5 0 100 200 300 400 500 0 100 200 300 400 500 5 5 F 0 0 -5 -5 0 100 200 300 400 500 0 100 200 300 400 500 5 5 G 0 0 -5 -5 0 100 200 300 400 500 0 100 200 300 400 500 Gating in Schizophrenia S1 S2 P50 N100 P200 1Red means greater than NC

  10. AUDITORY P300Bharat Bonala, Prashant Kota, Karthik Sunderasan, Nashaat N Boutros, and Ben H Jansen • Differences between normal and schizophrenia subjects. • Brain-Machine Interface.

  11. P300 and the Odd-Ball Paradigm 2 sec F F F R F F R F R F F Frequent/Non-Target stimulus P300: response to a relevant, infrequently occurring stimulus. R Rare/Target stimulus

  12. Normal Controls have larger P300 than Schizophrenia Patients

  13. A A B B C C D D E E F F G G H H I I K K L L J J A B C D E F M M N N Q Q R R O O P P G H I K L J U U V V W W X X T T S S M N Q R O P 3 3 4 4 Y Y Z Z 1 1 2 2 U V W X T S -- -- 5 5 6 6 7 7 8 8 9 9 3 4 Y Z 1 2 -- 5 6 7 8 9 Using the BMI HUNGRY HUNGRY THIRSTY THIRSTY LIGHT ON LIGHT ON LIGHT OFF LIGHT OFF Spelling Machine Donchin et al, IEEE-T-BME, 2000

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