Campylobacter
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Campylobacter:. C. Jejuni and C. coli have emerged as common human pathogens, causing mainly enteritis and occasionally systemic diseases. Morphology:

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Campylobacter

Campylobacter:

C. Jejuniand C. coli have emerged as common human pathogens, causing mainly enteritis and occasionally systemic diseases.

Morphology:

Small Gram negative bacilli, with comma or S shape. They are motile with single unsheathed polar flagellum, at one or both poles.


Campylobacter

Culture characters:

  • They are microaerophilic, best growth at 42⁰C in atmosphere containing 5% O₂ & 10% CO₂. They grow on a selective medium called Skirrow’s medium (containing lysed blood agar and vancomycin, polymyxin & trimethoprim).

    Method of transmission:

  • Usually, fecal-oral. Domestic animals such as cattle, chicken and dogs serve as a source of infection. Food and water contaminated with animal feces are the major source of human infection


Campylobacter

Pathogenesis:

  • C. jejuni is an invasive and toxogenic organism. It produce two exotoxins; enterotoxin and cytotoxin.

    Clinical picture:

  • Incubation period 3 days

  • Symptoms are severeng abdominal pain, nausea and diarrhea. Leucocytes are almost present in the feces, and frank blood may be apparent

  • Symptoms usually resolve within few days, but excretion of bacteria may continue for several weeks.


Campylobacter

  • ComplicationsAscptic arthritis or peripheral polyneuropathy (GuillainBarre’ syndrome; antibodies cross react with the myelin in nerve sheaths lead to symmetrical weakness).

    Laboratory diagnosis:

  • A stool specimen is cultured on Skirrow’s medium and incubated at 42⁰C in a microacrophilic atmosphere (5% O₂) containing 10% CO₂. The organism is defined by failure to grow at 25C, oxidase positive and catalase positive and sensitivity to antibiotics.


Campylobacter

  • Serology can he useful in patients presenting with aseptic arthritis or Guillain-Barre’ syndrome after about of diarrhea, Complement fixation test and ELISA tests can detect recent infection with C. jejuni and C. coli.

    Treatment:

  • Erythromycin, nalidixic acid and tetracyclines. Partially sensitive to ampicellin.


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