Sri Ram .P Date: 11/25/03 Course: Scientific Discovery Instructor: Dr. A. Vankley. Cell Mediated Immunity. “Discoveries concerning the specificities of Cell Mediated Immune defenses and their implications ”. Immunity?. Foreign Invaders. Self Markers. Markers of Non-Self.
Sri Ram .PDate: 11/25/03Course: Scientific Discovery
Instructor: Dr. A. Vankley
“Discoveries concerning the specificities of Cell Mediated Immune defenses and their implications ”
Natural Killer cells , Phagocytes and Granulocytes
In 1960-70s immunology was attempted to be understood in terms of infectious diseases. It was then Largely pre-occupied with antibody and T-cell responses against foreign protein antigens or chemically defined small molecules called haptens.
As peptides from viruses, bacteria and parasites are presented to the MHC class 1 or 2 molecules it was suggested that instead of live potentially harmful peptides could possibly be used as vaccines to induce T- cell responses.
Thus the combined efforts of doctors, immunologists, geneticists, virologists, microbiologists, etc helped us reveal the recognition of viral infected cells by T cells.
Giving insight into immunological specificity and memory and help understand immunological disease pathogenesis.
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