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Mitochondrial import machinery

Mitochondrial import machinery. Transclocation across the inner mitochondrial membrane. Peroxisomal import occurs through a common translocon. PTS1. PTS2. Pex5p. Pex7p. Pex14p. Pex17p. + addtl. factors. Pex13p. PTS1: C-term (S/C/A) (K/R/H) L. PTS2: bipartite N-term

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Mitochondrial import machinery

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  1. Mitochondrial import machinery

  2. Transclocation across the inner mitochondrial membrane

  3. Peroxisomal import occurs through a common translocon PTS1 PTS2 Pex5p Pex7p Pex14p Pex17p + addtl. factors Pex13p PTS1: C-term (S/C/A) (K/R/H) L PTS2: bipartite N-term (R/K) (L/V/I) XXXXX (H/Q) (L/A)

  4. Peroxisomal import occurs through a common translocon PTS1 PTS2 Pex5p Pex7p Pex14p Pex17p + addtl. factors Pex13p Peroxisomal biogenesis disorders (e.g. Zellweger syndrome) can affect peroxisomal transport and maintenance

  5. Peroxisomal import occurs posttranslational “extended shuttling” versus “simple shuttling” transport

  6. PMP1 PMP2 Pex19p ? “cytoplasmic chaperone” Pex3p “docking factor”

  7. Organelle inheritance and homeostasis

  8. Mitochondria are highly dynamic and undergo constant fusion and fission cycles

  9. Organelle inheritance Organelles must be faithfully and equally distributed - organelles cannot be generated de novo - mitochondria contain own DNA - etc. Organelles can be distributed stochastically or ordered

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