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CYCLO-OXYGÉNASE. CYTOCHROME P-450. 12-LIPOXYGÉNASE. 15-LIPOXYGÉNASE. 5-LIPOXYGÉNASE. La cascade de l’acide arachidonique. ACIDES EPOXY-EICOSATRIÈNOÏQUES, ETC. PROSTAGLANDINES. THROMBOXANE. COOH. ACIDE ARACHIDONIQUE (C20:4). 12-HETE. 15-HETE. HEPOXILINES. LEUCOTRIÈNES.

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slide1

CYCLO-OXYGÉNASE

CYTOCHROME P-450

12-LIPOXYGÉNASE

15-LIPOXYGÉNASE

5-LIPOXYGÉNASE

La cascade de l’acide arachidonique

ACIDES EPOXY-EICOSATRIÈNOÏQUES,

ETC

PROSTAGLANDINES

THROMBOXANE

COOH

ACIDE ARACHIDONIQUE (C20:4)

12-HETE

15-HETE

HEPOXILINES

LEUCOTRIÈNES

slide2

La voie de la 5-Lipoxygenase

COOH

ACIDE ARACHIDONIQUE (C20:4)

OOH

COOH

5-LIPOXYGÉNASE

5-HpETE

COOH

O

GLUTATHION-S-

TRANSFERASE

LTA4

OH

COOH

LTC4

S

CH

LTA4 HYDROLASE

2

C

H

(H20)

5

11

CHCONHCH

COOH

2

NHCOCH

CH

CHCOOH

2

2

LTB4

NH

HO

2

OH

COOH

slide3

Activités biologiques des leucotriènes

OH

COOH

S

CH2

HO

OH

C5H11

CHCONHCH2

COOH

COOH

NHCOCH2

CH2

CHCOOH

NH2

LEUCOTRIÈNE B4

(LTB4)

LEUCOTRIÈNE C4

(LTC4)

-Constriction des muscles lisses du

tract respiratoire

  • Activation & Chimiotaxisme
  • des phagocytes

- Augmente la permeabilité vasculaire

slide4

(AA LTA4 LTB4/LTC4)

Types de cellules impliquées dans la

synthèse de leucotriènes

A: exprimant la 5-lipoxygenase

Neutrophiles

LTB4

Eosinophiles

LTC4

Basophiles

LTC4

Monocytes

LTB4 + LTC4

Macrophages alvéolaires

LTB4

Macrophages péritonéaux

LTB4 + LTC4

Mastocytes

LTB4 + LTC4

slide5

(LTA4 LTB4/LTC4)

Types de cellules impliquées dans la

synthèse de leucotriènes

B: exprimant la LTA4 hydrolase ou la

GSH-transferase

Erythrocytes

Lymphocytes

Cellules endothéliales

Plaquettes

slide6

Voie de la Cyclooxygénase

COOH

O

•Vasodilatation

COOH

•Inhibition des

fonctions plaquettaires

OH

OH

AA

PGI2

Prostacyclin

Cyclooxygénase

Synthase

O

O

O

COOH

COOH

PGE2

COOH

Synthase

OH

O

•Vasodilatation

OH

OH

OH

PGE2

•Douleur

O

O

•Cartilage

PGG2

PGH2

Thromboxane

COOH

O

Synthase

O

OH

•Vasoconstriction

TXA2

•Aggrégation plaquettaire

slide7

O

COOH

O

COOH

O

OH

O

Métabolisme des acides gras n-3/n-6

COOH

(C20:4 n-6)

LTA4

PGG2

AA

(PGE2, PGI2, TXA2…)

(LTB4, LTC4,…)

(Aggrégation)

5-Lipoxygénase

Cyclooxygénase

(Chimiotaxisme)

EPA

(C20:5 n-3)

O

COOH

COOH

COOH

O

O

OH

O

LTA5

PGG3

(LTB5, LTC5,…)

(PGE3, PGI3, TXA3…)

(Moins actif)

(Pas d’aggrégation)