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Resveratrol. A Phytochemical With Health Benefits Found in Red Wine. Chem 11 Spring 2008. Resveratrol is a stilbene. Stilbene :. Resveratrol. Resveratrol. Health Benefits of Phytochemical s. Antoxidant activity Cancer inhibition Cholestrol regulation Anti-inflammatory activi ty.

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Resveratrol

Resveratrol

A Phytochemical With Health Benefits Found in Red Wine

Chem 11

Spring 2008


Resveratrol is a stilbene
Resveratrol is a stilbene

  • Stilbene:




Health benefits of phytochemical s
Health Benefits of Phytochemicals

  • Antoxidant activity

  • Cancer inhibition

  • Cholestrol regulation

  • Anti-inflammatory activity


  • What are Antioxidants?

    • They are substances that slow or prevent the oxidation of other molecules, particularly by such oxidizing agents as free radicals.

  • What are Free Radicals?

    • They are molecular or atomic species with one or more unpaired electrons making it very reactive.


Free radicals
Free Radicals

  • Where do they come from?

    • Many are produced in the body from O2 as part of normal metabolic activity.

    • Most of the O2 is consumed in the electron chain transport, but some escapes this pathway.


Free radical formation
Free Radical Formation

2O2 + NADPH 2O2- + NADP+ + H+

2O2- + 2H+ dismutase H2O2 + O2

H2O2 + O2- + H+ H2O + O2 + OH


Effects of free radicals

Negative Effects

Aging

Cancer

Disruption of normal cell activities

Heart disease

Damage DNA

Positive Effects

The body uses the most dangerous free radicals for use in the immune system and in inflammatory reactions.

Effects of Free Radicals


Other sources of free radicals
Other Sources of Free Radicals

  • Drugs

  • Air Pollution

  • Radiation, e.g. sunlight, TV and microwaves


Free radicals1
Free radicals

  • A common Free Radical is OH

  • This is created in body during normal metabolism in the ETC.


Free radicals attack cellular membranes
Free Radicals Attack Cellular Membranes

  • Free radicals break the double bonds of lipids found in cellular membranes:

    -C=C- + OH - C – C -

OH

OH


Antioxidants mop up loose free radicals
Antioxidants Mop Up Loose Free Radicals

+ OH

+ H2O

OH

OH

O

O

Antioxidant

Free Radical



Research studies of resveratrol
Research Studies Of Resveratrol

  • Studies are still in initial stages.

  • Anti-cancer, antiviral, neuroprotective, anti-aging and anti-inflammatory.

  • Anti-cancer – Resveratrolinterfers with all three stages; it has anti-angiogenic properties

  • Anti-aging – enzyme SIR2 increases life span of yeast cell and Resveratrol increases its activity

  • Drinking a glass of red wine a day may cut a man's risk of prostate cancer in half.


Bottom line
Bottom Line

There may not be enough Resveratrol in a glass of wine to yield clinical benefits, but it’s like chicken soup …

A little bit won’t hurt you and it might do you some good.


Works cited
Works cited

National Cancer Institution. “Antioxidants and Cancer Prevention: Fact Sheet.” 2008 May 10. <http://www.cancer.gov/ cancertopics/factsheet/antioxidantsprevention>.

National Cancer Institution. “Red Wine and Cancer Prevention: Fact Sheet.” 2008 May 10. <http://www.cancer.gov/ cancertopics/factsheet/red-wine-and-cancer-prevention>.

“New Insights into the Mechanism of Action of Antioxidants.” 2008 May 10 <http://ods.od.nih.gov/news/conferences/ ada2002/Milner_ abstract.html>

Sharma, H. M.D., C. Clark, M.D. An excerpt from the medical textbook Contemporary Ayurveda. Edinburgh: Churchill Livingstone, 1998. 2008 May 10.<http://www.bsherman.org/freeradicals.htm>.

Silverthorn, Dee Unglaub. Human Physiology: An Integrated Approach. 4th ed. San Francisco: Pearson

Educaton Inc. 2007. 22

J Bauer, D Sinclair, “Therapeutic potential of Resvertrol: the in vivo evidence”, National Revue Drug Discovery, 2006, 5(6): 494 – 506

K Huwitz, D Sinclair, “Small molecule activatiors of sirtuins extend Saccharomycescerevisiae lifespan”, Nature, 2003 Sep 11:425 191 – 6

Ming-Tsan Lin, Men-Luh Yen, Chia-Yi Lin, and Min-Liang Kuo, “Inhibition of Vascular Endothelial Growth Factor-Induced Angiogenesis by Resveratrol through Interruption of Src-Dependent Vascular Endothelial Cadherin Tyrosine Phosphorylation”, Mol Pharmacol 2003, 64:1029-1036


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