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Prions : The Newest Disease Agents. Do Now: Complete the chart on your notes as completely as possible. Transmissible Spongiform Encephalopathy (TSE). TSE is a group of diseases caused by prions . A prion is a disease-causing protein. Common types of TSE: “Mad Cow Disease” (BSE)

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Prions the newest disease agents

Prions: The Newest Disease Agents

Do Now:

Complete the chart on your notes as completely as possible


Transmissible spongiform encephalopathy tse
Transmissible Spongiform Encephalopathy (TSE)

  • TSE is a group of diseases caused by prions.

  • A prion is a disease-causing protein.

  • Common types of TSE:

    • “Mad Cow Disease” (BSE)

    • Scrapie

    • Kuru

    • Creutzfeldt-Jakob disease


How prions cause disease
How Prions Cause disease

  • This is a normal protein in your brain.

  • It has important functions your brain needs


Same protein 2 shapes
Same Protein, 2 Shapes

Normal

Protein

Disease

Protein

(prion)


When good proteins go bad
When Good Proteins Go Bad

  • The prion changes the shape of the normal protein, making it defective and infectious.


So what about the cow
So What About the Cow?

Brain tissue of infected cow: spongiform


Transmission cannibalism
Transmission: Cannibalism

  • Prions that cause disease are eaten, and then begin transforming proteins in the new victim.

  • Mad cow disease can be transmitted to humans (200+ known cases)

  • So how did cows get prions from other cows?


Rendering factories
Rendering Factories

  • Industrial animal production feeds animals the remains of dead animals.



Mmmm uncle larry
Mmmm… Uncle Larry!


The meatrix
The Meatrix

  • Industrial food production (CAFOs) have had major effects on human health, as demonstrated in this unit:

    • H1N1 influenza

    • BSE

  • Other implications we have not considered that affect humans:

    • Pollution (12,000,000 tons of animal waste/day)

    • Antibiotic resistance (70% of all antibiotics fed to animals)

    • Animal welfare



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