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The Digestive System

The Digestive System. Overview of the Digestive System. Organs are divided into two groups Alimentary canal Mouth, pharynx, and esophagus Stomach, small intestine, and large intestine Accessory digestive organs Teeth and tongue Gallbladder, salivary glands, liver, and pancreas.

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The Digestive System

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  1. The Digestive System

  2. Overview of the Digestive System • Organs are divided into two groups • Alimentary canal • Mouth, pharynx, and esophagus • Stomach, small intestine, and large intestine • Accessory digestive organs • Teeth and tongue • Gallbladder, salivary glands, liver, and pancreas

  3. Digestive Processes • Ingestion – occurs in the mouth • Propulsion – movement of food • Peristalsis – major means of propulsion • Mechanicaldigestion – prepares food for chemical digestion • Chewing, churning of food in stomach, segmentation • Chemical digestion – complex molecules broken down to chemical components • Mouth • Stomach • Small intestine • Absorption – transport of digested nutrients • Defecation – elimination of indigestible substances as feces

  4. Digestive Tract Smooth Muscle Movement • Peristalsis • Major means of propulsion • Adjacent segments of the alimentary canal relax and contract • Segmentation • Rhythmic local contractions of the intestine • Mixes food with digestive juices Figure 22.3a

  5. Histological Organization of Digestive Tract • Mucosa lines digestive tract (mucous epithelium) • Epithelium lines the lumen, moistened by secretions of mucosal glands • Lamina propria – loose areolar tissue • Muscularis mucosa – layer of smooth that creates folds called rugae • Submucosa - layer of dense irregular connective tissue, vascularized (blood and lymphatic), innervated – nerve plexus, submucosal glands • Muscularis externa - smooth muscle arranged in circular and longitudinal layers • Adventitia or Serosa - serous membrane made of areolar connective tissue with collagen and elastic fibers, covers most of the muscularis externa

  6. Digestive Tract Membranes • Peritoneum – a serous membrane • Parietal peritoneum – lines the body wall • Visceral peritoneum – surrounds digestive organs • Peritoneal cavity – a fluid filled space

  7. Digestive Tract Membranes • Mesentery – a double layer of peritoneum • Holds organs in place • Sites of fat storage • Provides a route for circulatory vessels and nerves

  8. Mesenteries • Greater omentum – a “fatty apron” of peritoneum • Attaches the greater curvature of the stomach to the dorsal body wall • Covers the transverse colon and a large part of the small intestine Figure 22.10c

  9. Mesenteries • Lesser omentum attaches to lesser curvature of stomach Figure 22.10b

  10. Oral cavity • Lined by oral mucosa = stratified squamous but no serosa • Roof of cavity = hard and soft palates • Uvula guards opening to pharynx • Floor of cavity = tongue • Mechanical processing • Assistance in chewing and swallowing • Sensory analysis by touch, temperature, and taste receptors

  11. The Oral Cavity • Its functions include: • Analysis of material before swallowing • Mechanical processing by the teeth, tongue, and palatal surfaces • Lubrication • Limited digestion Figure 24.6a, b

  12. Salivary glands (three pairs) • Parotid, sublingual, and submandibular • Produce saliva - watery solution includes electrolytes, buffers, glycoproteins, antibodies, enzymes • Functions include: lubrication, moistening, and dissolving, Initiation of digestion of complex carbohydrates

  13. Teeth • Function in mastication of bolus • Contain three layers • Enamel covering crown • Dentin forms basic structure • Root - periodontal ligaments hold teeth in alveoli • 20 primary teeth AKA deciduous teeth • 32 teeth of secondary dentition

  14. The Pharynx • Oropharynx and laryngopharynx • Common passageway for food, liquids, and air • Lined with stratified squamous epithelium, no serosa • External muscle layer • Consists of superior, middle, and inferior pharyngeal constrictors • Pharyngeal constrictor muscles assist in swallowing

  15. The Esophagus • Muscular tube - begins as a continuation of the pharynx • Carries solids and liquids from the pharynx to the stomach • Passes through esophageal hiatus in diaphragm • Joins the stomach inferior to the diaphragm • Cardiac sphincter – closes lumen to prevent stomach acid from entering esophagus • The wall of the esophagus contains mucosal (stratified squamous), submucosal, and muscularis layers

  16. The Esophagus • Epithelium is stratified squamous epithelium • When empty – mucosa and submucosa in longitudinal folds • Mucous glands – primarily compound tubuloalveolar glands • Muscularis externa • Skeletal muscle first third of length • Adventitia – most external layer

  17. The Stomach • Site where food is churned into chyme, Mechanical breakdown of food • Breaking of chemical bonds via acids and enzymes, decretion of pepsin and HCl begins protein digestion • Bulk storage of undigested food, food remains in stomach approximately 4 hours

  18. Anatomy Of The Stomach • Cardia – superior, medial portion • Fundus – portion superior to stomach-esophageal junction • Body – area between the fundus and the curve of the J • Pylorus – antrum and pyloric canal adjacent to the duodenum • Rugae - ridges and folds in relaxed stomach

  19. Microscopic Anatomy of the Stomach • Muscularis has three layers • Circular and longitudinal layers and oblique layer • Epithelium is simple columnar epithelium • Mucosa dotted with gastric pits holds gastric glands

  20. Microscopic Anatomy of the Stomach • Gastric glands of fundus and body • Mucous neck cells - secrete a special mucus • Parietal (oxyntic) cells - secrete hydrochloric acid and gastric intrinsic factor • Chief (zymogenic) cells - secrete pepsinogen • Glands produce 1500ml juice per day

  21. Small intestine • Longest portion of the alimentary canal • Site of most enzymatic digestion and absorption • Secretions and buffers provided by pancreas, liver, gall bladder • Three subdivisions: • Duodenum • Jejunum • Ileum • Ileocecal sphincter - transition between small and large intestine

  22. The Duodenum • Receives digestive enzymes and bile • Main pancreatic duct and common bile duct enter duodenum • Sphincters control entry of bile and pancreatic juices

  23. The Small Intestine – Microscopic Anatomy • Modifications for absorption • Circular folds (plicae circulares) - transverse ridges of mucosa and submucosa • Villi - finger-like projections of the mucosa, covered with simple columnar epithelium • Microvilli - further increase surface area for absorption • Lacteals - terminal lymphatic in villus

  24. Histology of the Intestinal Wall • Absorptive cells - uptake digested nutrients • Goblet cells - secrete mucus that lubricates chyme • Enteroendocrine cells - secrete hormones • Intestinal crypts - epithelial cells secrete intestinal juice

  25. Large Intestine • Digested residue contains few nutrients • Small amount of digestion by bacteria • Main functions • absorb water and electrolytes • compact material into feces • Absorb vitamins produced by bacteria • Store fecal matter prior to defecation

  26. Gross Anatomy of Large Intestine • Four areas of the colon • Ascending • Transverse • Descending • Sigmoid • Special features of large intestine • Teniae coli - thickening of longitudinal muscularis • Haustra - puckering created by teniae coli • Cecum - blind pouch, beginning of large intestine • Vermiform appendix - Contains lymphoid tissue

  27. The Rectum • Rectum - descends along the inferior half of the sacrum • Anal Canal - the last subdivision of the large intestine • Lined with stratified squamous epithelium • Last portion of the digestive tract • Terminates at the anal canal • Internal and external anal sphincters • Defecation reflex triggered by distention of rectal walls

  28. Microscopic Anatomy of Large Intestine • Villi are absent • Contains numerous goblet cells • Intestinal crypts – simple tubular glands • Lined with simple columnar epithelial tissue • Epithelium changes at anal canal, becomes stratified squamous epithelium

  29. The pancreas • Pancreatic duct penetrates duodenal wall • Endocrine functions - insulin and glucagons • Exocrine functions - majority of pancreatic secretions, pancreatic juice secreted into small intestine • Carbohydrases • Lipases • Nucleases • Proteolytic enzymes

  30. The Pancreas • Exocrine function • Acinar cells make, store, and secrete pancreatic enzymes • Enzymes are activated in the duodenum • Endocrine function • Produces insulin and glucagon • Regulates blood sugar

  31. The liver • Performs metabolic and hematological regulation and produces bile • Four Lobes: left, right, caudate, quadrate • Histological organization • Lobules containing single-cell thick plates of hepatocytes • Lobules empty into bile ducts, bile ducts merge to left/right hepatic ducts • L/R hepatic ducts merge to form common hepatic duct • Common hepatic meets cystic duct to form common bile duct

  32. Liver lobule - basic functional unit • Hepatocytes form irregular plates arranged in spoke-like fashion • Bile canaliculi carry bile to bile ductules • Bile ductules lead to bile ducts in portal areas

  33. The Gallbladder • Hollow, pear-shaped organ • Stores, modifies and concentrates bile • Bile – bile salts help buffer acids and acts as emulsifier for lipid digestion Figure 24.21a, b

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