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EBM --- Journal Reading

EBM --- Journal Reading. Presenter ： 傅雄威 Date ： 2005/10/27. Users’ Guides to the Medical Literature Ⅳ. How to Use an Article About Harm ？.

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EBM --- Journal Reading

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  1. EBM --- Journal Reading Presenter：傅雄威 Date：2005/10/27

  2. Users’ Guides to the Medical LiteratureⅣ.How to Use an Article About Harm？ Mitchell Levine, MD. MSc; Stephen Walter, PhD; Hui Lee , MD. MSc; Ted Haines, MD. MSc; Anne Holbrook, MD. PharmD MSc; Virginia Moyer, MD. MPH; for the Evidence-Based Medicine Working Group JAMA; May 25, 1994; 271, 20

  3. Clinical Scenario • Safety of beta-adrenergic agonists in the treatment of asthma • Antiarrhythmic agents (eg. encainide, flecainide and moricizine) is associated with incerased mortality.

  4. The SEARCH • MEDLINE • 38 citations:

  5. Guides: • Are the result of the study valid? • What are the results? • Will the result help me in the caring of my patients?

  6. Are the results valid? Primary guides: • Were there clearly identified comparison groups that were similar with respect to important determinants of outcome, other than the one of interest? • The design of the study determines the comparison groups.

  7. Randomized controlled Trials • The great strength is that we can be confident that the study groups were similar not only with respect to determinants of outcome that we know about, but also those we do not know. • Rarely done to study possible harmful exposure

  8. Cohort Studies • When it is either not feasible or not ethical to randomly assign patients to be exposed or not exposed to a putative causal agent. • When harmful outcomes are infrequent • Because subjects in a cohort study selected, therefore they are not similar

  9. Secondary guides: • Is the temporal relationship correct? • Is there a dose-response gradient?

  10. What are the results? • How strong is the association between exposure and outcome? • How precise is the estimate of the risk?

  11. Will the results help me in the caring of my patients? • Are the results applicable to my practice? • What is the magnitude of the risk? • Should I attempt to stop the exposure?

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