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2008 California Guideline for Alzheimer’s Disease Management

2008 California Guideline for Alzheimer’s Disease Management Debra Cherry, PhD Alzheimer’s Association, California Southland. Presenter Disclosures. The following financial relationships with commercial interests relevant to this presentation existed during the past 12 months:

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2008 California Guideline for Alzheimer’s Disease Management

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  1. 2008 California Guideline for Alzheimer’s Disease Management Debra Cherry, PhD Alzheimer’s Association, California Southland

  2. Presenter Disclosures • The following financial relationships with commercial interests relevant to this presentation existed during the past 12 months: • Grants to the Alzheimer’s Association, California Southland Chapter: • Forest Laboratories • Pfizer/Eisai • Janssen Pharmaceuticals • Novartis • Elan

  3. Objectives • Describe the process utilized to update the California Guideline for AD Management • Review the Guideline’s recommendations • Apply the recommendations to patients and caregivers • Use the Guideline to implement a quality improvement project

  4. What is a clinical guideline? • A document with the aim or guiding medical decisions and practice regarding: • Diagnosis • Management • Treatment • Briefly identifies, summarized and evaluates best evidence and most current data. Includes consensus statements from experts.

  5. History of California AD Management Guideline • 1995: California Workgroup on Guideline for Alzheimer’s Disease Management formed • 1998 Publication of the first Guideline • 2002 Guideline updated & published in The American Family Physician • 2008 Third update completed.

  6. Composition of the California Workgroup • Representatives from throughout the State: • Healthcare providers • Consumers • Academicians • Professional and volunteer organizations

  7. Purpose of the Guideline • Represents core care recommendations for AD management which are: • Based on scientific evidence • Supplemented by expert consensus • General guide to post-diagnostic care • Intended for Primary Care Practitioners including: • Physicians • Nurse Practitioners/Nurses • Physician Assistants • Also defines a role for: • Social Workers • Care Managers

  8. Mrs. R. L. Mrs. R. L. is a retired librarian who visits her physician for a routine follow-up for her osteoarthritis, GERD, and glaucoma. She has enjoyed her 3 years of retirement, but reports that recently her husband has been worried about her memory. Mrs. L. states that she had started writing reminder notes, “which don’t always help.” She admits to reading less than she used to; she also drives less because “traffic is such a problem.”

  9. Mrs. R. L. Mr. L. reports that his wife often returns from grocery shopping having forgotten to pick up several things that she intended to buy. At other times she will wander through the house, looking in drawers or closets for items that she had put away for safe-keeping. Although they used to go out to dinner at least once a week, they now go much less frequently because Mrs. L. states that “I just never know what to order, and it’s not as much fun as it used to be.”

  10. Dementia Warning Signs

  11. Dementia Warning Signs

  12. What signs and symptoms are present in Mrs. R. L. that suggest that she may have a dementia?

  13. Guideline for AD Management • Assessment • Treatment • Patient & Family Education & Support • Legal Considerations

  14. Assessment • Cognitive status • Daily function • Concurrent medical conditions • Medications • Behavior symptoms and mood • Living arrangements • Support system

  15. Assessing Cognition

  16. Assessment: Function Activities of Daily Living (ADL) • Self-feeding • Dressing • Ambulation • Toileting • Bathing • Transfer from bed to toilet • Continence • Grooming • Communication

  17. Assessment: FunctionInstrumental ADL (IADL) • Writing • Reading • Cooking • Cleaning • Shopping • Doing laundry • Climbing stairs • Using telephone • Managing medication • Managing money • Ability to perform outside work • Ability to travel (public transportation)

  18. Assessment: Concurrent Conditions • Chronic disease • Ability to manage • Acute Conditions • Delirium • Infection/UTI/Influenza

  19. Assessment: Medications & Cognition • Anticholinergics • Benzodiazepines • Sleep aids • Antipsychotics • Narcotics • Muscle relaxants • NSAIDs • Anti-arrhythmics • Antihypertensives • Cimetidine • Corticosteroids • Hypoglycemic agents

  20. Assessment: Behavior & Mood • Agitation • Restlessness • Irritability • Aggression • Psychosis • Delusions • Paranoia • Hallucinations • Depression • Withdrawal • Sleep disturbances • Appetite changes • Apathy • Loss if interest

  21. Assessment: Living Arrangements • Declining ability for self-care • Patient autonomy vs. need for care • Safety issues • Rugs, appliances • Driving • Abuse and neglect • Dependence • Caregiver stress

  22. Assessment: Support System • Family’s ability to care for patient • Community supports • Alzheimer’s Association • Caregiver Resource Center • Religious or other groups • Community resources – day care, in-home care • Health care resources • Advance directives

  23. Mrs. R has come to the Alzheimer’s Disease Center and been thoroughly assessed. She has been determined to have a diagnosis of Alzheimer’s disease. What next?

  24. Treatment: Develop a Treatment Plan • Improve cognitive function • Increase level of function • Delay disease progression • Manage behavior disturbances • Ease caregiver burden

  25. Treatment: Improve Cognitive Function • Cholinergic manipulation • Cholinesterase inhibitors • All agents block acetylcholinesterase activity • Rivastigmine also blocks butyrylcholinesterase • Galantamine stimulates cholinergic receptors • NMDA antagonist • Reduces glutamate activity • Regulates calcium entry into cells

  26. Counseling Points • Effects on cognition are very mild • May stabilize or slow decline • May improve independence, self-care • Gastrointestinal effects are prominent • May slow heart rate

  27. TREATMENT Recommendations • Treat behavioral symptoms and mood disorders using: • Non-pharmacologic approaches, such as environmental modification, task simplification, appropriate activities, etc. • IF non-pharmacological approaches prove unsuccessful, THEN use medications, targeted to specific behaviors, if clinically indicated. Note that side effects may be serious and significant.

  28. Treatment: Behavior Symptoms • Most difficult for both patients and caregivers • Behavior symptoms contribute to: • Patient distress • Caregiver burnout • Excess disability • Institutionalization

  29. Behavioral Symptoms as AD Progresses 100 Agitation 80 Diurnal Rhythm 60 Depression Irritability Prevalence (% of patients) Wandering Social Withdrawal Aggression 40 Mood Change Anxiety Hallucinations Paranoia 20 Socially Unacceptable Delusions Suicidal Ideation Accusatory Sexually Inappropriate 0 –30 –20 –10 0 10 20 30 –40 Months Before Diagnosis Months After Diagnosis Jost BC, Grossberg GT. J Am Geriatr Soc. 1996;44:1078-1081.

  30. Mrs. R. L. Some time has passed and Mr. L. is concerned about changes in his wife’s behavior. She becomes agitated, especially in the late afternoon and leaves the house. She says she is going home and gets more agitated when he reminds her that she is in her home.

  31. Evaluating Behaviors • Rapid onset requires search for medical cause • Pain, infection, adverse drug effect • Identify problem • Antecedents - Behaviorial triggers • Behaviors – Be Specific • Consequences

  32. Common Causes of Challenging Behaviors • Health problems • Difficult tasks • Confusing environment • Communication breakdown • Patient’s perceptions of the situation

  33. What may be triggering Mrs. L.’s behavior? What does this behavior mean to her? How should these symptoms be managed?

  34. Mrs. R. L. Mrs. R. L. has begun a daily exercise program and late afternoon agitation is now less of an issue. However, at night she awakens and becomes agitated. She believes someone is trying to break into the house. When her husband tries to reassure her, she gets angry and strikes out at him.

  35. What may be triggering Mrs. L.’s behavior? What does this behavior mean to her? How should these symptoms be managed?

  36. PATIENT and FAMILY EDUCATION & SUPPORT Recommendations • Integrate medical care with education & support by connecting patient & caregiver to support organizations • - Alzheimer’s Association 1-800-272-3900 www.alz.org • - Family Caregiver Alliance 1-800-445-8106 www.caregiver.org- or your own social service department.

  37. PATIENT and FAMILY EDUCATION & SUPPORT Early Stages Pay particular attention to the special needs of early-stage patients, involving them in care planning, heeding their opinions and wishes, and referring them to community resources, including the Alzheimer’s Association.

  38. PATIENT and FAMILY EDUCATION & SUPPORT End of Life Decisions Discuss the intensity of care and other end-of-live care decisions with the Alzheimer’s Disease patient and involved family members while respecting their cultural preferences.

  39. LEGAL CONSIDERATIONS Recommendations • Include a discussion of the importance of basic legal and financial planning as part of the treatment plan as soon as possible after the diagnosis of AD. • Monitor for evidence of and report all suspicions of abuse as required by law. • Report the diagnosis of AD in accordance with local laws.

  40. Using the Guideline in a Health Care Setting Health care organizations are challenged to care for the growing number of older adults with chronic health conditions

  41. How to use Guidelines for a QI project: • Set quality goals derived from guideline • Train practitioners • Add case management • Evaluate

  42. Implementation Support Tools • Provider Tool Kit • Medical Record Checklist • List of Reversible Medical Conditions • Signs/Symptoms of Elder Abuse • Mental Status Exam • Safe Return / ID Bracelet Program Application • Dementia and Driving Reporting Law • Prescription Pad

  43. QI Projects Using Guidelines • Kaiser Permanente – Metro L.A. • ACCESS – Kaiser, Scripps & • U.C.S.D. Healthcare • HealthCare Partners Medical Group • SCAN HealthPlan

  44. Establishing Partnerships Replication Manual Based on Alzheimer’s Association – Kaiser Permanent Metropolitan Los Angeles Dementia Care Project www.alz.org/california southland Click on Professional Training then scroll down to Replication Manual

  45. Got Guideline? 2008 California Guideline for Alzheimer’s Disease Management Available at: www.caalz.org or contact Amy.Landers@alz.org 323-930-6289

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