GTP

1. Abbrev Intermediates II 7,8-dihydroneopterin triphosphate II´ 7,8-dihydromonapterin triphosphate IIa 7,8-dihydroneopterin monophosphate III folic acid IV tetrahydrofolate monoglutamate ± C1 substituents V 7,8-dihydroneopterin (Vox = neopterin) V´ 7,8-dihydromonapterin (V´ox = monapterin) VI 6-hydroxymethyl-7,8-dihydropterin VII 6-hydroxymethyl-7,8-dihydropterin pyrophosphate VIII dihydropteroate IX dihydrofolate X tetrahydrofolate XI tetrahydrofolate polyglutamates XII chorismate XIII 4-amino-4-deoxychorismate XIV p-aminobenzoic acid III Outside III GTP NADPH DHFR II´ V´ Glycolaldehyde L-Glu, ATP ADP, Pi PPi folQ folP H20 ATP AMP folC folB folX folB NADP DHNTPase VII VI VIII IX II IIa V GCHY-I NP DHNA HPPK DHPS DHFS NADPH folK folE NADP DHFR folA Formate PPi Pi XIV PTR1 PTR1 PTR1 Pyruvate NADP X NADPH ADC Lyase pabAc ATP + Glu Vox V´ox VIox FPGS folC XIII ADP + Pi Glu XI pabAab ADC Synthase Gln XII One carbon metabolism IV Shikimate pathway XIV IV Pterin branch and de novo pABA branch Intact folate salvage Pterin salvage pABA salvage THF-monoglutamate salvage