Heather Brodkin Computationally Guided Protein- Specific Labeling with NPs Adam Hendricks Synthesis of Spin Labeled Na

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IGERT NANOMEDICINE SCIENCE AND TECHNOLOGY Multi-disciplinary courses Introduction to Nanomedical Technology ; Nanosystems Design for Biomedical Applications; Scientific Skills, Ethics, and Commercialization; Nanomedicine Seminar Internships and outreach Community engagement Intellectual property Cultural diversity International outlook Communication Skills Professional Conduct Reports Publications Presentations Research Integrity Ethics An Interdisciplinary Doctoral Training Program IGERT NANOMEDICINE VISION Funded by the National Science Foundation Inter-disciplinary research Nanoplatforms for targeted delivery; Optical sensors and therapies; Magnetic nanoplatforms; Nanoplatforms for Antimicrobial, Implant and Neural applications; Ethical and Policy issues in Nanomedicine www.igert.neu.edu Doctoral Trainees The Faculty Program Vision The IGERT Nanomedicine PhD program recruits students from various disciplines (Biology, Chemistry, Physics, Engg, and Pharmaceutical Sciences) to work collaboratively on Nanomedicine related projects. The IGERT Ph.D Trainee will graduate with a Ph.D. degree in their core subject with specialization in Nanomedicine Science and Technology. In Phase – I, 26 Ph.D. students representing 3 colleges and 9 Departments have been trained. IGERT fellows have contributed to excellent research that has resulted in over 50 journal publications , 1 patent approved, 2 patents filed, 15 book chapters, 3 books and over 125 conference presentations and posters. A few representative projects are listed below. Director and PI: Srinivas Sridhar Co-PIs: Mansoor Amiji , Laura H. Lewis, Carlos Rinaldi, Tamara Floyd-Smith Dattatri Nagesha (Research Coordinator), Rita Kaderian (Program Coordinator) The Integrative Graduate Education, Research & Training (IGERT) program in Nanomedicine Science and Technology was established at Northeastern University in 2005 (Phase 1) with funding from the National Science Foundation. The IGERT Nanomedicine program aims to train the next generation of scientists and technologists who are skilled in research at the interface of nanotechnology, biology and medicine, who are aware of the path to translate fundamental knowledge to marketplace products, who are informed of the ethical and social issues relating to the discipline, and who have a strong sense of community involvement as well as a global perspective. The program received funding for a second phase Phase 2 (2010-2015), with additional partners – Tuskegee University and University of Puerto Rico, Mayaguez, as well as faculty from Harvard Medical School, to establish a national multi-site training program. International partners have also expressed an eagerness to replicate the model in their institutions. IGERT Faculty Collaborators/Advisors Biology: K. Lewis, D. O'Malley, C. Warner, E.Cram Chemistry: M. Diem, G. Jones, R. Hanson, M.Ondrechen Physics: D. Heiman, L. Menon, M. Williams Pharmaceutical Sciences: A. Makryannis, V. Torchilin, B.Waszczak, Chemical Engg: R. Carrier, S. Murthi, L.P.Murphy Mech and Ind Engg: J.Ruberti Elec and Comp Engg: C. Di Marzio, N. Sun (TU) Materials Science and Engg: Vijaya Rangari Integrative Biosciences: Clayton Yates, Timothy Turner (UPRM) Applied Chemistry: Oscar Perales-Perez, Marco DeJesus, Felix Roman Chemical Engg: Carlos Rinaldi, Madeline Torres Materials Science: Surinder Singh, Marcelo Suarez VISITING FACULTY MENTORS T. Hassan – MGH M. Makrigiorgos- DFCI N. Soukos – Forsyth O. Farokhzad – BWH S. Sengupta – BWH M. Harisinghani – MGH N.Goldberg – BIDMC A. Patri - NCL Heather Brodkin Computationally Guided Protein- Specific Labeling with NPs Adam Hendricks Synthesis of Spin Labeled Nanosensors for the Estrogen Receptor Tatyana Chernenko Raman Micro-spectroscopic Techniques for Drug-delivery Applications Agnes Rafalko Gold NPs for imaging cell surface oligosaccharides for early diagnosis of cancer Paula Lampton Using NPs to Analyze Key Immune System Molecules in Embryonic Stem Cells Anthony D’Onofrio Nanoparticle Antimicrobial Development Sucharita Saha Visualization and Enhancement of Spinal Cord Regeneration using Nanoparticles Robert Camp: MIE Quantifying Collagen’s Mechanosensitivity to Enzymatic Cleavage by MMPs Savidra Lucatero: ChemE Transport Behavior of Drugs and NPs Intestinal Mucus Yogesh Patel: ECE Basal Cell Carcinoma Brian Plouffe:Chem E Microfluidic Cell Separation Using Functionalized Magnetic NPs Lilian van Vlerken Development of a Polymeric NP Formulation to Overcome Multidrug Resistance of Cancer via a Multifunctional Therapy Mattia Migliore Intranasal Delivery of GDNF for the Treatment of Parkinson’s Disease Luis Brito Endothelial Nitric Oxide Synthase (eNOS) Gene Therapy with Gelatin-Based Nanovectors Lara Jabr Mitochondriotropic Gold NP Vectors Thomas Barchet Role of Polyunsaturated Fatty Acid-Containing nano-emulsions in Drug Delivery and Neuroprotection in Alzheimer’s Disease. Chemistry Research • The tightly-integrated interdisciplinary team of medical researchers, pharmaceutical scientists, physicists, chemists, and chemical engineers, has an extensive range of expertise to facilitate research on nanomedicine: • Nanotechnology platforms such as polymeric nanoparticles, lipid nanoparticles, metal nanoparticles, and self-assembling nanosystems, • Synthetic chemistry to design and optimize new strategies for nanoparticle preparation and functionalization, • Cancer diag-nostic and imaging techniques using nano-particles as reporter platforms and contrast enhancing agents, • Therapeutic targeted and intra-cellular drug and gene delivery using nanocarriers, • Nanoparticles for electromagnetic hyper/hypothermia and imaging • Theoretical modeling of nanoparticle processes in biological and medical environments, and of drug and gene delivery, • Clinical diagnosis and therapy of prostate, breast, and liver cancer. Pharmaceutical Sciences Outreach IGERT Outreach provides education and leadership skills to both students and teachers from participating schools in the Greater Boston area. Outreach activities including RET, the Young Scholars Program, Field Trip hosting, and Science Fair Mentoring have proven to be a very positive experience to all involved. Engineering Biology Facilities The Nanomedicine Core Facility has been established to provide nanoparticles and nanomaterials for various interdisciplinary research projects. Facility includes: Hitachi 2nm Hi Res FESEM, SQUID, AFM, STM, TEM, NSOM Associates:The IGERT Associate Program is intended for Undergraduates and Masters students interested in the area of nanomedicine. The program has supported over 32 students from 8 different departments that include Physics, Chemistry, Biotechnology, Pharmaceutical Sciences, Mechanical and Industrial Engg, Electrical and Computer Engg, Chemical Engg and Biology. The research experience has influenced several of these students to pursue graduate education. Partners and Collaborators