STUDY UPDATE

1. The Stroke Oxygen Study Summer 2009 Newsletter SOS CO-ORDINATING CENTRE STUDY UPDATE NEW SITES! Welcome to the following new SOS recruiting sites: Mid Staffordshire Hospital, Royal Bournemouth, Bishop Auckland General Hospital, University Hospital of North Durham, St Helens & Knowsley, Doncaster Royal Infirmary, Medway Hospital, Leighton Hospital, Southend University Hospital, Blackpool Victoria Hospital, University Hospital Aintree, Leeds Teaching Hospital, Wansbeck & North Tyneside Hospitals, Salford Royal Hospital, Norfolk & Norwich University Hospital, Kings College, Macclesfield General Hospital, Barnsley Hospital, Wigan Hospital, Royal Wolverhampton Hospital, South Tyneside General Hospital Dates for the Diary – UK STROKE FORUM 2009 After last years success we will be having a stand at the UK Stroke Forum in Glasgow (1-3 Dec 09). Please visit us on stand 41 Collaborators meeting – we will also be having a collaborators meeting at the UK Stroke Forum on Thursday 3rd Dec at 8am. We look forward to seeing you there. SO2SAcute Stroke Training Days With the NIHR CRN the SOS study ran 2 training days in Birmingham (May) and London (July). The sessions included a clinical background to the study and protocol review, an obtaining consent for the study session – with a researchers experience, a potential problems and clinical benefit of the study. The sessions were interactive to allow lots of discussion and recruitment tips. These were well attended and received positive feedback. Thanks for all who attended. • RECRUITMENT • Total: 286 • (up to 1st July ‘09) • No. of Active centers: 40 • No. of centres awaiting approval: 48 • No. of centres expressing an interest: 11 CENTRE RECRUITMENT We are still looking for more centres — should you wish to be involved or know of a prospective centre please contact Sarah Pountain (Study co-ordinator).

2. Recruitment SOS patient recruitment (April ’08 – 1st July ‘09) SOS - Hints and Tips NIHSS Dr Roffe presented an update on the SOS study at the SRN conference in Newcastle on the 8-9th July 2009. During this she discussed the current spread of NIHSS scores recruited into the study. In order to obtain unbiased data she would like to recruit more sever strokes to the study as well as the mild ones. This is an acute stroke trial and Dr Roffe has said “it is important to get a true picture of the use of oxygen treatment for the full range of strokes – from the mild to acute range”. Data entry Many thanks for all your hard work in inputting the data promptly – can we take this opportunity to remind you to complete the week 1 contact details (with a 2nd contact address) AND to remember to hit submit once the data has been saved. CONGRATULATIONS! • To: • Dr Church & team at Uni. Hospital of North Durham • Dr Mukerjee & team at Queens, Burton • Dr Husain & team at Musgrove Park • Dr Dixit & team at Freeman and Royal Victoria • For being the highest recruiters in May and June • To: • Ashford & St Peters, • Birmingham Heartlands • Bishop Auckland • Brighton & Sussex • Freeman & Royal Victoria • Leighton Hospital • Royal Bournemouth • Royal Liverpool • Southend Hospital • Royal Sunderland Hospital • University Hospital of BirminghamUniversity Hospital of North Durham • Yeovil Hospital • For recruiting their 1st SOS patients

3. Site Recruitment