The Beta-Lactam Antibiotics. Cell wall active agents Prevent the final step in the synthesis of the bacterial cell wall Range from very narrow spectrum to very broad spectrum. β -lactam ring. β -Lactams. How do they work?. The β -lactam binds to Penicillin Binding Protein (PBP)
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“Penicillin binding protein”
Enterococcus [Amp 2g IV q4h]
*Not effective vs. Enterococcus or Listeria