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Cocaine, Amphetamines, Caffeine, Nicotine

Cocaine, Amphetamines, Caffeine, Nicotine. Tintinalli Chapter 168. Cocaine. Absorbed from all mucosal surfaces Local anesthetic and CNS stimulant Symptoms Mydriasis Tachycardia, HTN Diaphoresis Euphoria. Amphetamines. Routes Ingestion IV Inhalation Insufflation Popular Drugs

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Cocaine, Amphetamines, Caffeine, Nicotine

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  1. Cocaine, Amphetamines, Caffeine, Nicotine Tintinalli Chapter 168

  2. Cocaine • Absorbed from all mucosal surfaces • Local anesthetic and CNS stimulant • Symptoms • Mydriasis • Tachycardia, HTN • Diaphoresis • Euphoria

  3. Amphetamines • Routes • Ingestion • IV • Inhalation • Insufflation • Popular Drugs • Ritalin • Action • Enhance release and block reuptake of catecholamines

  4. Cardiac Dysrhythmias Myocarditis, cardiomyopathies MI CNS Seizures Infarctions / bleeds Focal vasospasm Pulmonary More common with crack cocaine Pulmonary edema GI Mesenteric vasospasm Body packing Renal Rhabdomyolysis Clinical Features

  5. Treatment • ABC • Charcoal • Sedation • Tachycardia – benzos • No haldol, droperidol • Seizures • Chest pain in association • No Beta adrenergic antagonists Sir, after reviewing your tests, I know why you are having chest pain. You are ALLERGIC TO COCAINE. Have a nice day – go home.

  6. Caffeine • Similar to theophylline • Routes • IV, IM, SC, PR • Clinical • Enhances cognitive and motor abilities (low dose) • Overdose ~1gram • GI symptoms • tachycardia, agitation

  7. Questions

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