Solar activity as a dominant factor
This presentation is the property of its rightful owner.
Sponsored Links
1 / 21

Solar activity as a dominant factor in the external impact on the persistence PowerPoint PPT Presentation


  • 82 Views
  • Uploaded on
  • Presentation posted in: General

Solar activity as a dominant factor in the external impact on the persistence of H.pylori in the body ? J.A.Belaya, O.F.Belaya, V.G.Petrukhin FGBU SRIEM by N.F.Gamaleia I.M. Sechenov First Moscow State Medical University Moscow , 2012. Helicobacter pylori. Kurskmed.ru. Imedic.biz.

Download Presentation

Solar activity as a dominant factor in the external impact on the persistence

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Solar activity as a dominant factor in the external impact on the persistence

Solar activity as a dominant factor

in the external impact on the persistence

of H.pylori in the body?

J.A.Belaya, O.F.Belaya, V.G.Petrukhin

FGBU SRIEM by N.F.Gamaleia

I.M. Sechenov First Moscow State Medical University

Moscow, 2012


Helicobacter pylori

Helicobacter pylori

Kurskmed.ru

Imedic.biz

WWW.rid.ru


Interaction of h pylori with cells

Interaction of H.pylori with cells

Hsp60

TLR2

H.pylori

TLR5

X

TLR5

NOD1 (IV )

(Algood H.M.S., Cover T.L., 2006)


Contingent of examineer and the number of bioassays 1999 2012

Contingent of examineer and the number of bioassays (1999-2012)

---------------------------------------------------------------------------------------------------------

25 8941

520 1120

7500 8500

43 96

27 44

25 50

35 95

58 269

91 283

---------------------------------------------------------------------------------------------------------

8324 19398


Methods

Methods

O- H.pylori

VacA- H.pylori


The frequency of h pylori o antigen volunteer a 1999 2011 3532 s of saliva

The frequency of H.pylori O-antigen (volunteer A., 1999-2011, 3532 s. of saliva)


Seasonal detection of o antigen in patients with h pylori nud ag cg ud ei 2005 2008

Seasonal detection of O-antigen in patients with H.pylori NUD, AG, CG, UD, EI (2005-2008)


Identification of free h pylori o antigen and vaca in cic

Identification of free H.pylori O-antigen and VacA in CIC


Identification of free h pylori o antigen and vaca in cic and mal with o antigen

Identification of free H.pylori O-antigen and VacA in CIC and MAL with O-antigen


Solar activity as a dominant factor in the external impact on the persistence

O-antigen of H. pylori in saliva

and VacA in the CIC during the day

(volunteer in February 2007)

14

24

0

9


The frequency of h pylori o antigen and vaca in chronic gastroduodenitis 1999 2011

The frequency of H.pylori O-antigen and VacA in chronic gastroduodenitis (1999-2011)


Ises solar cycle sunspot number progression 0 vaca antigens of h pylori

ISES Solar cycle sunspot number progression, 0-, VacA-antigens of H.pylori


Solar activity as a dominant factor in the external impact on the persistence

Monthly frequency of O-and VacA-H.pylori antigens and solar activity (Wolf number)(volunteer 1, 2006-2012, 1184 saliva samples)


Solar activity as a dominant factor in the external impact on the persistence

The frequency of 0-ag and VacAH.pyloriand monthly solar activity(volunteer number 1, 2006 2012, 1184 samples of saliva)


Solar activity as a dominant factor in the external impact on the persistence

  • - 0- VacA- H.pylori , , , , . , , , , 11- .

  • Conclusion

Its were identified regular cyclic changes of the occurrence of a pathogenetically important 0 - and VacA- H.pylori antigens in the body of volunteers, patients with enteric infections and with GID, reflecting the vital activity of the causative agent and the state of the immunity of the host, their mutual adaptation under the influence of internal and external factors. These cyclical changes are observed during the day, month, year, season, the 11-year SA cycle.


Solar activity as a dominant factor in the external impact on the persistence

  • VacA , , - , 2-3- , -- .

- Detection frequency VacA in the CIC, in general, is higher than the frequency of detection of O-Ag in feces, with the exception of spring and autumn months of the year and 2-3-year periods of decrease in immunity, when the risk of exacer-bation of HP-associated diseases increases.


Solar activity as a dominant factor in the external impact on the persistence

  • - ( ) - - - , - .

-The comparison of obtained data on vital functions of the HP with SA (Wolf numbers) showed high correlation of average monthly and annual rises of the circulation of 0-Ag with the corresponding rises SA, as well as the higher rate of O-antigens in periods of higher CA compared with periods of lower CA.


Solar activity as a dominant factor in the external impact on the persistence

  • , -, : CA 23 24 , - , .. - , .

  • One of the dominant factors of external influence, apparently, is the SA: the greatest decrease in immunity observed in years of maximum CA 23 and 24 solar cycle, but other factors are not excluded,as changes in tandem parasite-host begin earlier than the rise of solar activity.


Solar activity as a dominant factor in the external impact on the persistence

  • , , - -, - , , ,

  • Knowledge of the patterns of circulation of free and connected in immune complex Hp-toxins, taking into account SA changes can predict the risk of exacerbations of helicobacteriosis to prevent them, calculate index of individual probability of infection, improve diagnosis, treatment and prevention, and is important for scientific research on the mechanisms of persistence of microbes.


Solar activity as a dominant factor in the external impact on the persistence

  • - .

  • .

  • It was accumulated large factual material, that can be used in further searches of other significant factors affecting the persistence of pathogen in the human body.

  • It is necessary to continue and expand this study


Thank you for your attention

Thank you for your attention !


  • Login